Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus

Axel Fischer, Bradley J. Undem

Research output: Contribution to journalArticle

Abstract

The recently identified endogenous agonists on the μ-opioid-receptor (μOR), endomorphin-1 (EM-1) and endomorphin-2 (EM-2), induce a concentration dependent inhibition of electrical field stimulation (EFS)-induced tachykinin-mediated contractions of the guinea-pig bronchus (ED(50s) < 10 nM for both compounds). Surprisingly, only endomorphin-1 effects could be blocked by naloxone (10 μM), whereas endomorphin-2 effects were not affected by specific antagonists for the μ-, κ-, and δ-opioid-receptor.

Original languageEnglish (US)
Pages (from-to)605-608
Number of pages4
JournalBritish Journal of Pharmacology
Volume127
Issue number3
DOIs
StatePublished - Jun 24 1999

Keywords

  • Endomorphin
  • Guinea-pig
  • Opioid receptors
  • Sensory nerves
  • Tachykinins

ASJC Scopus subject areas

  • Pharmacology

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