Nalmefene: Blockade of intravenous morphine challenge effects in opioid abusing humans

Hendrée E. Jones; Rolley E. Johnson; Paul J. Fudala; Jack E. Henningfield; Stephen J. Heishman

doi:10.1016/S0376-8716(00)80005-8

Nalmefene: Blockade of intravenous morphine challenge effects in opioid abusing humans

Hendrée E. Jones, Rolley E. Johnson, Paul J. Fudala, Jack E. Henningfield, Stephen J. Heishman

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

No studies have assessed the dose-effect or duration of opioid blockade in opioid abusers produced by oral nalmefene, a μ-opioid antagonist. The present study examined the profile and time course of oral nalmefene blockade of subjective and physiological effects produced by intravenous morphine. To assess these effects, seven opioid abusers received oral nalmefene (0, 50 and 100 mg) followed by intravenous morphine (0, 10 and 20 mg) challenges every 24 h for 96 h using a Latin square randomized cross-over design. The duration of blockade varied by measure and dose. Both 50 and 100 mg nalmefene blocked morphine's effects up to 48 h. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	29-37
Number of pages	9
Journal	Drug and alcohol dependence
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/S0376-8716(00)80005-8
State	Published - Jul 1 2000

Keywords

Blockade
Morphine
Nalmefene
Pharmacology
Subjective effects

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/S0376-8716(00)80005-8

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title = "Nalmefene: Blockade of intravenous morphine challenge effects in opioid abusing humans",

abstract = "No studies have assessed the dose-effect or duration of opioid blockade in opioid abusers produced by oral nalmefene, a μ-opioid antagonist. The present study examined the profile and time course of oral nalmefene blockade of subjective and physiological effects produced by intravenous morphine. To assess these effects, seven opioid abusers received oral nalmefene (0, 50 and 100 mg) followed by intravenous morphine (0, 10 and 20 mg) challenges every 24 h for 96 h using a Latin square randomized cross-over design. The duration of blockade varied by measure and dose. Both 50 and 100 mg nalmefene blocked morphine's effects up to 48 h. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

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author = "Jones, {Hendr{\'e}e E.} and Johnson, {Rolley E.} and Fudala, {Paul J.} and Henningfield, {Jack E.} and Heishman, {Stephen J.}",

note = "Funding Information: The authors thank Tim Mudric and Linda Felch for statistical assistance as well as nursing and research assistant staff at the National Insititute on Drug Abuse (NIDA) for their contributions. This research was supported in part by the NIDA Intramural Research Program and grant T32-DA07209.",

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AU - Jones, Hendrée E.

AU - Johnson, Rolley E.

AU - Fudala, Paul J.

AU - Henningfield, Jack E.

AU - Heishman, Stephen J.

N1 - Funding Information: The authors thank Tim Mudric and Linda Felch for statistical assistance as well as nursing and research assistant staff at the National Insititute on Drug Abuse (NIDA) for their contributions. This research was supported in part by the NIDA Intramural Research Program and grant T32-DA07209.

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N2 - No studies have assessed the dose-effect or duration of opioid blockade in opioid abusers produced by oral nalmefene, a μ-opioid antagonist. The present study examined the profile and time course of oral nalmefene blockade of subjective and physiological effects produced by intravenous morphine. To assess these effects, seven opioid abusers received oral nalmefene (0, 50 and 100 mg) followed by intravenous morphine (0, 10 and 20 mg) challenges every 24 h for 96 h using a Latin square randomized cross-over design. The duration of blockade varied by measure and dose. Both 50 and 100 mg nalmefene blocked morphine's effects up to 48 h. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - No studies have assessed the dose-effect or duration of opioid blockade in opioid abusers produced by oral nalmefene, a μ-opioid antagonist. The present study examined the profile and time course of oral nalmefene blockade of subjective and physiological effects produced by intravenous morphine. To assess these effects, seven opioid abusers received oral nalmefene (0, 50 and 100 mg) followed by intravenous morphine (0, 10 and 20 mg) challenges every 24 h for 96 h using a Latin square randomized cross-over design. The duration of blockade varied by measure and dose. Both 50 and 100 mg nalmefene blocked morphine's effects up to 48 h. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Blockade

KW - Morphine

KW - Nalmefene

KW - Pharmacology

KW - Subjective effects

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Nalmefene: Blockade of intravenous morphine challenge effects in opioid abusing humans

Abstract

Keywords

ASJC Scopus subject areas

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