Abstract
Fourteen novel 4-aminoquinazoline derivatives 2–15 were designed and synthesized. The structure of the newly synthesized compounds was established on the basis of elemental analyses, IR, 1H-NMR, 13C-NMR, and mass spectral data. The compounds were evaluated for their potential cytoprotective activity in murine Hepa1c1c7 cells. All of the synthesized compounds showed concentration-dependent ability to induce the cytoprotective enzyme NAD(P)H: quinone oxidoreductase (NQO1) with potencies in the low- to sub-micromolar range. This approach offers an encouraging framework which may lead to the discovery of potent cytoprotective agents.
Original language | English (US) |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Journal of Enzyme Inhibition and Medicinal Chemistry |
DOIs | |
State | Accepted/In press - Jan 20 2016 |
Keywords
- 4-aminoquinazoline
- cytoprotective
- NAD(P)H
- synthesis
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology