NADPH oxidase: Recent evidence for its role in erectile dysfunction

Liming Jin, Arthur L. Burnett

Research output: Contribution to journalReview article

Abstract

Important roles for reactive oxygen species (ROS) in physiology and pathophysiology have been increasingly recognized. Under normal conditions, ROS serve as signaling molecules in the regulation of cellular functions. However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes significantly to the pathogeneses of vascular diseases. Although it has become evident that increased ROS is associated with erectile dysfunction (ED), the sources of ROS in the penis remain largely unknown. In recent years, emergent evidence suggests the possible role of NADPH oxidase in inducing ED. In this review, we examine the relationship between ROS and ED in different disease models and discuss the current evidence basis for NADPH oxidase-derived ROS in ED.

Original languageEnglish (US)
Pages (from-to)6-13
Number of pages8
JournalAsian Journal of Andrology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Erectile function
  • Nitric oxide
  • Penis
  • Reactive oxygen species
  • Superoxide

ASJC Scopus subject areas

  • Urology

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