N-Myristoylglutamic acid derivative of 3′-fluoro-3′- deoxythymidine as an organogel

Bhupender S. Chhikara, Rakesh Tiwari, Keykavous Parang

Research output: Contribution to journalArticlepeer-review

Abstract

Designing microbicidal gels of anti-HIV drugs for local application to prevent HIV infection is a subject of major interest. 3′-Fluoro-3′- deoxythymidine (FLT), a nucleoside reverse transcriptase inhibitor (NRTI), was conjugated with a N-myristoylglutamate scaffold. The conjugate showed gelation at 1% (w/w) in different organic solvents, such as toluene, dichloromethane, and chloroform. The gels were opaque and stable at room temperature. The results indicate that myristoyl glutamate derivative of FLT can form an organogel. The gel could have potential application as a topical anti-HIV microbicidal agent.

Original languageEnglish (US)
Pages (from-to)5335-5337
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number39
DOIs
StatePublished - Sep 26 2012
Externally publishedYes

Keywords

  • Amino acid
  • Anti-HIV drugs
  • FLT
  • Glutamate
  • NRTI
  • Nucleoside
  • Organogel
  • Peptide
  • Reverse transcriptase

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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