(N-Methyl-[11C])pyrilamine, a radiotracer for histamine H-1 receptors: Radiochemical synthesis and biodistribution study in mice

Kazuhiko Yanai, Robert F. Dannals, Alan A. Wilson, Hayden T. Ravert, Ursula Scheffel, Shuji Tanada, Henry N. Wagner

Research output: Contribution to journalArticle


The histamine H-1 receptor antagonist, pyrilamine (N-((4-methoxyphenyl)methyl)-N′,N′-dimethyl-N-2-pyridinyl-1,2-ethanediamine) was labeled with carbon-11 by N-alkylation of desmethylpyrilamine with [11C]iodomethane, and purified by preparative high performance liquid chromatography. The chemically and radiochemically pure labeled pyrilamine was obtained with specific activity of approximately 2500 mCi/μmol (EOS). In vivo distribution studies in mice suggest that the distribution of this compound parallels the known histamine H-1 receptor density in the brain.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation.
Issue number6
StatePublished - 1988


ASJC Scopus subject areas

  • Medicine(all)

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