TY - JOUR
T1 - N-Methyl-D-Aspartate Antagonist D-APV Selectively Disrupts Taste-Potentiated Odor Aversion Learning
AU - Willner, Jeffrey
AU - Gallagher, Michela
AU - Graham, Phillip W.
AU - Crooks, Geoffrey B.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 1992/4
Y1 - 1992/4
N2 - Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 μg/side icv) caused stereospecific deficits in potentiated odor aversion learning but left simple taste and odor aversion learning intact. In Experiment 2, pretreatment with D-APV had no effect on rats' acquisition of an illness-based odor discrimination task. These results parallel those previously obtained using a noncompetitive NMDA antagonist (Robinson, Crooks, Shinkman, & Gallagher, 1989) and show that interference with NMDA receptors can selectively impair potentiated odor aversion learning. These results suggest that NMDA receptors play a critical role in some, but not all, forms of learning and memory.
AB - Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 μg/side icv) caused stereospecific deficits in potentiated odor aversion learning but left simple taste and odor aversion learning intact. In Experiment 2, pretreatment with D-APV had no effect on rats' acquisition of an illness-based odor discrimination task. These results parallel those previously obtained using a noncompetitive NMDA antagonist (Robinson, Crooks, Shinkman, & Gallagher, 1989) and show that interference with NMDA receptors can selectively impair potentiated odor aversion learning. These results suggest that NMDA receptors play a critical role in some, but not all, forms of learning and memory.
UR - http://www.scopus.com/inward/record.url?scp=0026724924&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026724924&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.106.2.315
DO - 10.1037/0735-7044.106.2.315
M3 - Article
C2 - 1350450
AN - SCOPUS:0026724924
SN - 0735-7044
VL - 106
SP - 315
EP - 323
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 2
ER -