Abstract
This Editorial highlights a study by Koliou X et al. in the current issue of Journal of Neurochemistry, in which the authors demonstrate that neurofibromin is transported to the nucleus in a cell cycle-dependent manner in astrocytic cells. During mitosis in their model, neurofibromin localizes in particular to the mitotic spindle where it binds to tubulin through a C-terminal domain phosphorylated at Ser 2808 (left). Depletion of neurofibromin leads to non-aligned chromosomes during metaphase, or abnormal congression (right), a process that may affect tumorigenesis in neoplasms with neurofibromin loss through chromosome instability and aneuploidy. Read the full article 'Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression' on page 78.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-12 |
| Number of pages | 2 |
| Journal | Journal of Neurochemistry |
| Volume | 136 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
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ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience
Cite this
N for nucleus in neurofibromin : New role for an old tumor suppressor? / Rodriguez, Fausto J.
In: Journal of Neurochemistry, Vol. 136, No. 1, 01.01.2016, p. 11-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - N for nucleus in neurofibromin
T2 - New role for an old tumor suppressor?
AU - Rodriguez, Fausto J
PY - 2016/1/1
Y1 - 2016/1/1
N2 - This Editorial highlights a study by Koliou X et al. in the current issue of Journal of Neurochemistry, in which the authors demonstrate that neurofibromin is transported to the nucleus in a cell cycle-dependent manner in astrocytic cells. During mitosis in their model, neurofibromin localizes in particular to the mitotic spindle where it binds to tubulin through a C-terminal domain phosphorylated at Ser 2808 (left). Depletion of neurofibromin leads to non-aligned chromosomes during metaphase, or abnormal congression (right), a process that may affect tumorigenesis in neoplasms with neurofibromin loss through chromosome instability and aneuploidy. Read the full article 'Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression' on page 78.
AB - This Editorial highlights a study by Koliou X et al. in the current issue of Journal of Neurochemistry, in which the authors demonstrate that neurofibromin is transported to the nucleus in a cell cycle-dependent manner in astrocytic cells. During mitosis in their model, neurofibromin localizes in particular to the mitotic spindle where it binds to tubulin through a C-terminal domain phosphorylated at Ser 2808 (left). Depletion of neurofibromin leads to non-aligned chromosomes during metaphase, or abnormal congression (right), a process that may affect tumorigenesis in neoplasms with neurofibromin loss through chromosome instability and aneuploidy. Read the full article 'Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression' on page 78.
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UR - http://www.scopus.com/inward/citedby.url?scp=84951083209&partnerID=8YFLogxK
U2 - 10.1111/jnc.13435
DO - 10.1111/jnc.13435
M3 - Article
C2 - 26690015
AN - SCOPUS:84951083209
VL - 136
SP - 11
EP - 12
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 1
ER -