TY - JOUR
T1 - N-acetylaspartylglutamate
T2 - An endogenous peptide with high affinity for a brain 'glutamate' receptor
AU - Zaczek, R.
AU - Koller, K.
AU - Cotter, R.
AU - Heller, D.
AU - Coyle, J. T.
PY - 1983
Y1 - 1983
N2 - A brain peptide with high affinity (420 nM) and marked specificity for brain receptor sites labeled with L-[3H]glutamate has been identified. Amino acid analysis and mass spectroscopy indicate that the peptide is N-acetylaspartylglutamate. The peptide exhibits potent convulsant properties when injected into the rat hippocampus, similar to those produced by the glutamate receptor agonist, quisqualic acid. These findings raise the question whether endogenous brain peptides enriched in acidic amino acids may serve as excitatory neurotransmitters.
AB - A brain peptide with high affinity (420 nM) and marked specificity for brain receptor sites labeled with L-[3H]glutamate has been identified. Amino acid analysis and mass spectroscopy indicate that the peptide is N-acetylaspartylglutamate. The peptide exhibits potent convulsant properties when injected into the rat hippocampus, similar to those produced by the glutamate receptor agonist, quisqualic acid. These findings raise the question whether endogenous brain peptides enriched in acidic amino acids may serve as excitatory neurotransmitters.
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U2 - 10.1073/pnas.80.4.1116
DO - 10.1073/pnas.80.4.1116
M3 - Article
C2 - 6302671
AN - SCOPUS:0011920660
VL - 80
SP - 1116
EP - 1119
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
IS - 4 I
ER -