(N-[11C]-methyl)doxepin: Synthesis of a radiotracer for studying the histamine H-1 receptor

H. T. Ravert, R. F. Dannals, A. A. Wilson, H. N. Wagner

Research output: Research - peer-reviewArticle

Abstract

Doxepin (3-dibenz [b,e] oxepin - 11(6H)-ylidene-N,N-dimethyl-1-propanamine), a potent H1 histamine antagonist, was labeled with 11C-iodomethane by N-alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

LanguageEnglish (US)
Pages403-407
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number5
StatePublished - 1992

Fingerprint

Doxepin
Histamine
N-methyl doxepin
Histamine Antagonists
Alkylation
methyl iodide
Purification

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

(N-[11C]-methyl)doxepin : Synthesis of a radiotracer for studying the histamine H-1 receptor. / Ravert, H. T.; Dannals, R. F.; Wilson, A. A.; Wagner, H. N.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 31, No. 5, 1992, p. 403-407.

Research output: Research - peer-reviewArticle

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