(N-[11C]-methyl)doxepin: Synthesis of a radiotracer for studying the histamine H-1 receptor

H. T. Ravert, Robert F Dannals, A. A. Wilson, H. N. Wagner

Research output: Contribution to journalArticle

Abstract

Doxepin (3-dibenz [b,e] oxepin - 11(6H)-ylidene-N,N-dimethyl-1-propanamine), a potent H1 histamine antagonist, was labeled with 11C-iodomethane by N-alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number5
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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