(N‐[11C]‐Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H‐1 receptor

Hayden T. Ravert; Robert F. Dannals; Alan A. Wilson; Henry N. Wagner

doi:10.1002/jlcr.2580310510

(N‐[¹¹C]‐Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H‐1 receptor

Hayden T. Ravert, Robert F. Dannals, Alan A. Wilson, Henry N. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H₁ histamine antagonist, was labeled with ¹¹C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

Original language	English (US)
Pages (from-to)	403-407
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	31
Issue number	5
DOIs	https://doi.org/10.1002/jlcr.2580310510
State	Published - May 1992

Keywords

Doxepin
carbon‐11
histamine
positron emission tomography

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.2580310510

Cite this

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title = "(N‐[11C]‐Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H‐1 receptor",

abstract = "Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H1 histamine antagonist, was labeled with 11C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).",

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author = "Ravert, {Hayden T.} and Dannals, {Robert F.} and Wilson, {Alan A.} and Wagner, {Henry N.}",

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AU - Dannals, Robert F.

AU - Wilson, Alan A.

AU - Wagner, Henry N.

PY - 1992/5

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AB - Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H1 histamine antagonist, was labeled with 11C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

KW - Doxepin

KW - carbon‐11

KW - histamine

KW - positron emission tomography

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