Myostatin and the control of skeletal muscle mass

Se Jin Lee, Alexandra C. McPherron

Research output: Contribution to journalArticle

Abstract

The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and raises the possibility that growth inhibitors may also be involved in regulating the size of other tissues.

Original languageEnglish (US)
Pages (from-to)604-607
Number of pages4
JournalCurrent Opinion in Genetics and Development
Volume9
Issue number5
DOIs
StatePublished - Oct 1 1999

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Myostatin
Skeletal Muscle
Chalones
Growth Inhibitors
Growth

ASJC Scopus subject areas

  • Genetics

Cite this

Myostatin and the control of skeletal muscle mass. / Lee, Se Jin; McPherron, Alexandra C.

In: Current Opinion in Genetics and Development, Vol. 9, No. 5, 01.10.1999, p. 604-607.

Research output: Contribution to journalArticle

Lee, Se Jin ; McPherron, Alexandra C. / Myostatin and the control of skeletal muscle mass. In: Current Opinion in Genetics and Development. 1999 ; Vol. 9, No. 5. pp. 604-607.
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