TY - JOUR
T1 - Myostatin and the control of skeletal muscle mass
AU - Lee, Se Jin
AU - McPherron, Alexandra C.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and raises the possibility that growth inhibitors may also be involved in regulating the size of other tissues.
AB - The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and raises the possibility that growth inhibitors may also be involved in regulating the size of other tissues.
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U2 - 10.1016/S0959-437X(99)00004-0
DO - 10.1016/S0959-437X(99)00004-0
M3 - Comment/debate
C2 - 10508689
AN - SCOPUS:0032871622
SN - 0959-437X
VL - 9
SP - 604
EP - 607
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -