Myositis Mimics

E. Harlan Michelle, Andrew L. Mammen

Research output: Contribution to journalReview articlepeer-review

Abstract

Patients with autoimmune myositis typically present with muscle weakness, elevated serum levels of muscle enzymes, and abnormal muscle biopsies. However, patients with other acquired myopathies or genetic muscle diseases may have remarkably similar presentations. Making the correct diagnosis of another muscle disease can prevent these patients from being exposed to the risks of immunosuppressive medications, which benefit those with myositis, but not those with other types of muscle disease. Here, we review some of the most common acquired and inherited muscle diseases that can mimic autoimmune myositis, including inclusion body myositis, limb girdle muscular dystrophies, metabolic myopathies, mitochondrial myopathies, and endocrine myopathies. We emphasize aspects of the medical history, physical exam, laboratory evaluation, and muscle biopsy analysis that can help clinicians distinguish myositis mimics from true autoimmune myositis.

Original languageEnglish (US)
Article number63
JournalCurrent rheumatology reports
Volume17
Issue number10
DOIs
StatePublished - Oct 21 2015

Keywords

  • Acid maltase deficiency
  • Autoimmune myopathies
  • Dysferlinopathy
  • Endocrine myopathies
  • Facioscapulohumeral muscular dystrophy
  • Inclusion body myositis
  • McArdle’s disease
  • Mitochondrial myopathies

ASJC Scopus subject areas

  • Rheumatology

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