Abstract
Purpose of Review: To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies. Recent Findings: Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease. Summary: As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.
Original language | English (US) |
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Pages (from-to) | 602-608 |
Number of pages | 7 |
Journal | Current opinion in rheumatology |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2012 |
Keywords
- autoantibodies
- autoantigens
- dermatomyositis
- myositis
- necrotizing myopathy
ASJC Scopus subject areas
- Rheumatology