Myositis autoantibodies

Livia Casciola-Rosen, Andrew L. Mammen

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations


Purpose of Review: To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies. Recent Findings: Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease. Summary: As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalCurrent opinion in rheumatology
Issue number6
StatePublished - Nov 2012


  • autoantibodies
  • autoantigens
  • dermatomyositis
  • myositis
  • necrotizing myopathy

ASJC Scopus subject areas

  • Rheumatology


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