Myositis: An update on pathogenesis

Lisa Christopher-Stine, Paul H. Plotz

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of review: The etiology and much about the pathogenesis of the inflammatory myopathies remain a mystery. In this review, we investigate recent research efforts to understand the pathogenesis of the diverse entities of polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM), diseases that result from interactions between environmental risk factors and genetic susceptibility. Recent findings: Over the past year, there has been considerable progress toward better understanding of IBM, with relatively few developments toward understanding PM and DM. Although these diseases may share some common clinical phenotypic and serologic components, they differ on a molecular and cellular level. Summary: The need for definitive, safer therapies in these diseases makes vital the search for defining detailed pathogenesis of inflammation and muscle fiber damage at the molecular level.

Original languageEnglish (US)
Pages (from-to)700-706
Number of pages7
JournalCurrent opinion in rheumatology
Volume16
Issue number6
DOIs
StatePublished - Nov 2004

Keywords

  • Dermatomyositis
  • Inclusion body myositis
  • Inflammatory myopathy
  • Pathogenesis
  • Polymyositis

ASJC Scopus subject areas

  • Rheumatology

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