TY - JOUR
T1 - Myositis
T2 - An update on pathogenesis
AU - Christopher-Stine, Lisa
AU - Plotz, Paul H.
PY - 2004/11
Y1 - 2004/11
N2 - Purpose of review: The etiology and much about the pathogenesis of the inflammatory myopathies remain a mystery. In this review, we investigate recent research efforts to understand the pathogenesis of the diverse entities of polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM), diseases that result from interactions between environmental risk factors and genetic susceptibility. Recent findings: Over the past year, there has been considerable progress toward better understanding of IBM, with relatively few developments toward understanding PM and DM. Although these diseases may share some common clinical phenotypic and serologic components, they differ on a molecular and cellular level. Summary: The need for definitive, safer therapies in these diseases makes vital the search for defining detailed pathogenesis of inflammation and muscle fiber damage at the molecular level.
AB - Purpose of review: The etiology and much about the pathogenesis of the inflammatory myopathies remain a mystery. In this review, we investigate recent research efforts to understand the pathogenesis of the diverse entities of polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM), diseases that result from interactions between environmental risk factors and genetic susceptibility. Recent findings: Over the past year, there has been considerable progress toward better understanding of IBM, with relatively few developments toward understanding PM and DM. Although these diseases may share some common clinical phenotypic and serologic components, they differ on a molecular and cellular level. Summary: The need for definitive, safer therapies in these diseases makes vital the search for defining detailed pathogenesis of inflammation and muscle fiber damage at the molecular level.
KW - Dermatomyositis
KW - Inclusion body myositis
KW - Inflammatory myopathy
KW - Pathogenesis
KW - Polymyositis
UR - http://www.scopus.com/inward/record.url?scp=7244253273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7244253273&partnerID=8YFLogxK
U2 - 10.1097/01.bor.0000141925.21941.d8
DO - 10.1097/01.bor.0000141925.21941.d8
M3 - Review article
C2 - 15577607
AN - SCOPUS:7244253273
SN - 1040-8711
VL - 16
SP - 700
EP - 706
JO - Current opinion in rheumatology
JF - Current opinion in rheumatology
IS - 6
ER -