@article{5860b646a4a34f13a7d1f848f930762c,
title = "Myosin IIb Regulates actin dynamics during synaptic plasticity and memory formation",
abstract = "Reorganization of the actin cytoskeleton is essential for synaptic plasticity and memory formation. Presently, the mechanisms that trigger actin dynamics during these brain processes are poorly understood. In this study, we show that myosin II motor activity is downstream of LTP induction and is necessary for the emergence of specialized actin structures that stabilize an early phase of LTP. We also demonstrate that myosin II activity contributes importantly to an actin-dependent process that underlies memory consolidation. Pharmacological treatments that promote actin polymerization reversed the effects of a myosin II inhibitor on LTP and memory. We conclude that myosin II motors regulate plasticity by imparting mechanical forces onto the spine actin cytoskeleton in response to synaptic stimulation. These cytoskeletal forces trigger the emergence of actin structures that stabilize synaptic plasticity. Our studies provide a mechanical framework for understanding cytoskeletal dynamics associated with synaptic plasticity and memory formation.",
author = "Rex, {Christopher S.} and Gavin, {Cristin F.} and Rubio, {Maria D.} and Kramar, {Eniko A.} and Chen, {Lulu Y.} and Yousheng Jia and Huganir, {Richard L.} and Nicholas Muzyczka and Gall, {Christine M.} and Miller, {Courtney A.} and Gary Lynch and Gavin Rumbaugh",
note = "Funding Information: We would like to thank Dr. J. David Sweatt for his many helpful discussions and critical evaluation of the manuscript. We would also like to thank Huashi Li, Ryley Parrish, and Anupam Sharma for their support and technical assistance. This work was supported by UAB start-up funds, The McKnight Brain Institute, The Alabama Health Sciences Foundation and National Institute of Neurological Disorders (NINDS) grant NS064079 (G.R), NINDS grants NS05182 (G.L.), and NS45260 (G.L. and C.M.G.). L.Y.C. was supported by National Institute of Mental Health grant MH083396. C.S.R. was supported by National Institute on Aging grant AG00096, NINDS grant 045540, and the Kauffman Foundation. N.M. is an inventor of patents related to rAAV technology and owns equity in a gene therapy company that is commercializing AAV for gene therapy applications. ",
year = "2010",
month = aug,
doi = "10.1016/j.neuron.2010.07.016",
language = "English (US)",
volume = "67",
pages = "603--617",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}