Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Jan Kottwitz; Katelyn A. Bruno; Jan Berg; Gary R. Salomon; De Lisa Fairweather; Mawahib Elhassan; Nora Baltensperger; Christine K. Kissel; Marina Lovrinovic; Andrea Baltensweiler; Christian Schmied; Christian Templin; Joao A.C. Lima; Ulf Landmesser; Thomas F. Lüscher; Robert Manka; Bettina Heidecker

doi:10.1007/s12265-020-09957-8

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Jan Kottwitz, Katelyn A. Bruno, Jan Berg, Gary R. Salomon, De Lisa Fairweather, Mawahib Elhassan, Nora Baltensperger, Christine K. Kissel, Marina Lovrinovic, Andrea Baltensweiler, Christian Schmied, Christian Templin, Joao A.C. Lima, Ulf Landmesser, Thomas F. Lüscher, Robert Manka, Bettina Heidecker

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r_s = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (r_s = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]

Original language	English (US)
Pages (from-to)	853-863
Number of pages	11
Journal	Journal of cardiovascular translational research
Volume	13
Issue number	5
DOIs	https://doi.org/10.1007/s12265-020-09957-8
State	Published - Oct 1 2020

Keywords

Biomarker
Cardiac enzymes
Late gadolinium enhancement
Magnetic resonance imaging
Myocardial inflammation
Myocarditis
Myoglobin
Troponin

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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10.1007/s12265-020-09957-8

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Kottwitz, J., Bruno, K. A., Berg, J., Salomon, G. R., Fairweather, D. L., Elhassan, M., Baltensperger, N., Kissel, C. K., Lovrinovic, M., Baltensweiler, A., Schmied, C., Templin, C., Lima, J. A. C., Landmesser, U., Lüscher, T. F., Manka, R., & Heidecker, B. (2020). Myoglobin for Detection of High-Risk Patients with Acute Myocarditis. Journal of cardiovascular translational research, 13(5), 853-863. https://doi.org/10.1007/s12265-020-09957-8

Kottwitz, J, Bruno, KA, Berg, J, Salomon, GR, Fairweather, DL, Elhassan, M, Baltensperger, N, Kissel, CK, Lovrinovic, M, Baltensweiler, A, Schmied, C, Templin, C, Lima, JAC, Landmesser, U, Lüscher, TF, Manka, R & Heidecker, B 2020, 'Myoglobin for Detection of High-Risk Patients with Acute Myocarditis', Journal of cardiovascular translational research, vol. 13, no. 5, pp. 853-863. https://doi.org/10.1007/s12265-020-09957-8

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abstract = "There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]",

keywords = "Biomarker, Cardiac enzymes, Late gadolinium enhancement, Magnetic resonance imaging, Myocardial inflammation, Myocarditis, Myoglobin, Troponin",

author = "Jan Kottwitz and Bruno, {Katelyn A.} and Jan Berg and Salomon, {Gary R.} and Fairweather, {De Lisa} and Mawahib Elhassan and Nora Baltensperger and Kissel, {Christine K.} and Marina Lovrinovic and Andrea Baltensweiler and Christian Schmied and Christian Templin and Lima, {Joao A.C.} and Ulf Landmesser and L{\"u}scher, {Thomas F.} and Robert Manka and Bettina Heidecker",

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AU - Kottwitz, Jan

AU - Bruno, Katelyn A.

AU - Berg, Jan

AU - Salomon, Gary R.

AU - Fairweather, De Lisa

AU - Elhassan, Mawahib

AU - Baltensperger, Nora

AU - Kissel, Christine K.

AU - Lovrinovic, Marina

AU - Baltensweiler, Andrea

AU - Schmied, Christian

AU - Templin, Christian

AU - Lima, Joao A.C.

AU - Landmesser, Ulf

AU - Lüscher, Thomas F.

AU - Manka, Robert

AU - Heidecker, Bettina

PY - 2020/10/1

Y1 - 2020/10/1

N2 - There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]

AB - There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]

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KW - Cardiac enzymes

KW - Late gadolinium enhancement

KW - Magnetic resonance imaging

KW - Myocardial inflammation

KW - Myocarditis

KW - Myoglobin

KW - Troponin

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Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Abstract

Keywords

ASJC Scopus subject areas

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