Myoelectric activity differences in acute and chronic models of lamb intestinal atresia

Nancy A. Pawlik, Franklin E. Hardy, J. Laurance Hill

Research output: Contribution to journalArticle

Abstract

Clinical and experimental investigations of intestinal atresia have reduced mortality and clarified etiology. However, the morbidity of this lesion remains excessive and its pathophysiology uncertain. The purpose of this project was to produce the first long-term model of intestinal atresia and thereby to study the motility of the adapting bowel. Intestinal atresia was induced in nine fetal lambs at midgestation by mesenteric avulion. At term, this experimental group and eight control lambs underwent resection with anastomosis, decompression gastrostomy, and implantation of electrodes proximal and distal to the anastomosis. Vigorous resuscitation and constant intensive care were critical for survival. Slow wave activity (SWA) and spike potential activity (SPA) were recorded in the first 24 hours and every 48 hours thereafter for a 6-hour interval. Three of nine lambs with atresia and five of the eight control animals survived over 48 hours (chronic). Analysi of 220 hours of recording showed, in the first 24 hours of life, a statistically significantly different SWA of 16.4 cycles/min (±1.15 SD) in the chronic atretic survivors compared with 13.1 cycles/min (±2.6 SD) in the acute (died

Original languageEnglish (US)
Pages (from-to)1203-1206
Number of pages4
JournalJournal of Pediatric Surgery
Volume22
Issue number12
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Intestinal Atresia
Activity Cycles
Gastrostomy
Critical Care
Decompression
Resuscitation
Action Potentials
Survivors
Electrodes
Morbidity
Control Groups
Survival
Mortality

Keywords

  • Intestinal atresia
  • intestinal motility
  • myoelectric activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. / Pawlik, Nancy A.; Hardy, Franklin E.; Hill, J. Laurance.

In: Journal of Pediatric Surgery, Vol. 22, No. 12, 1987, p. 1203-1206.

Research output: Contribution to journalArticle

Pawlik, Nancy A. ; Hardy, Franklin E. ; Hill, J. Laurance. / Myoelectric activity differences in acute and chronic models of lamb intestinal atresia. In: Journal of Pediatric Surgery. 1987 ; Vol. 22, No. 12. pp. 1203-1206.
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