Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling

Heung Sun Kwon; Thomas V. Johnson; Myung Kuk Joe; Mones Abu-Asab; Jun Zhang; Chi Chao Chan; Stanislav I. Tomarev

doi:10.1074/jbc.M112.446138

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling

Heung Sun Kwon, Thomas V. Johnson, Myung Kuk Joe, Mones Abu-Asab, Jun Zhang, Chi Chao Chan, Stanislav I. Tomarev

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.

Original language	English (US)
Pages (from-to)	26357-26371
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	37
DOIs	https://doi.org/10.1074/jbc.M112.446138
State	Published - Sep 13 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling",

abstract = "Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.",

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AU - Johnson, Thomas V.

AU - Joe, Myung Kuk

AU - Abu-Asab, Mones

AU - Zhang, Jun

AU - Chan, Chi Chao

AU - Tomarev, Stanislav I.

PY - 2013/9/13

Y1 - 2013/9/13

N2 - Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.

AB - Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.

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Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling

Abstract

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