Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling

Heung Sun Kwon, Thomas V. Johnson, Myung Kuk Joe, Mones Abu-Asab, Jun Zhang, Chi Chao Chan, Stanislav I. Tomarev

Research output: Contribution to journalArticle

Abstract

Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.

Original languageEnglish (US)
Pages (from-to)26357-26371
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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