Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling

Heung Sun Kwon, Thomas Johnson, Myung Kuk Joe, Mones Abu-Asab, Jun Zhang, Chi Chao Chan, Stanislav I. Tomarev

Research output: Contribution to journalArticle

Abstract

Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.

Original languageEnglish (US)
Pages (from-to)26357-26371
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number37
DOIs
StatePublished - Sep 13 2013

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Peripheral Nervous System
Neurology
Sciatic Nerve
Glaucoma
Demonstrations
Defects
Mutation
trabecular meshwork-induced glucocorticoid response protein
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Kwon, H. S., Johnson, T., Joe, M. K., Abu-Asab, M., Zhang, J., Chan, C. C., & Tomarev, S. I. (2013). Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. Journal of Biological Chemistry, 288(37), 26357-26371. https://doi.org/10.1074/jbc.M112.446138

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. / Kwon, Heung Sun; Johnson, Thomas; Joe, Myung Kuk; Abu-Asab, Mones; Zhang, Jun; Chan, Chi Chao; Tomarev, Stanislav I.

In: Journal of Biological Chemistry, Vol. 288, No. 37, 13.09.2013, p. 26357-26371.

Research output: Contribution to journalArticle

Kwon, Heung Sun ; Johnson, Thomas ; Joe, Myung Kuk ; Abu-Asab, Mones ; Zhang, Jun ; Chan, Chi Chao ; Tomarev, Stanislav I. / Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 37. pp. 26357-26371.
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