TY - JOUR
T1 - Myocardial T1 and extracellular volume fraction mapping at 3 tesla
AU - Lee, Jason J.
AU - Liu, Songtao
AU - Nacif, Marcelo S.
AU - Ugander, Martin
AU - Han, Jing
AU - Kawel, Nadine
AU - Sibley, Christopher T.
AU - Kellman, Peter
AU - Arai, Andrew E.
AU - Bluemke, David A.
N1 - Funding Information:
Research funding was provided by the NIH intramural research program. We thank Jacquin L. Jones, RN for recruiting the volunteers.
PY - 2011
Y1 - 2011
N2 - Background: To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). Methods. Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus. Results: T1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 39 ms and 2020 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 1.0%. Conclusion: The 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.
AB - Background: To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). Methods. Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus. Results: T1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 39 ms and 2020 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 1.0%. Conclusion: The 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.
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U2 - 10.1186/1532-429X-13-75
DO - 10.1186/1532-429X-13-75
M3 - Article
C2 - 22123333
AN - SCOPUS:84860565995
SN - 1097-6647
VL - 13
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
IS - 1
M1 - 75
ER -