Myocardial stunning and preconditioning: Potential clinical implications

W. D. Gao, E. Marbán

Research output: Contribution to journalReview articlepeer-review

Abstract

Mycordial stunning is caused by decreased myofilament sensitivity to Ca2+ after ischemia. Ischemia preconditioning is an adoptive response to brief ischemia insults which renders the heart resistant to lethal injury. Both have a clear clinical implications. The former rationalizes the common postoperative requirement for intensive short-term inotropic support in patients who eventually proceed to recovery, while the later may help to limit ischemic damage during cardioplegia and hypothermic circulatory arrest.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalProblems in Anesthesia
Volume13
Issue number2
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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