Myocardial structure, function, and scar in patients with type 1 diabetes mellitus

Evrim B. Turkbey, Jye Yu C Backlund, Saul Genuth, Aditya Jain, Cuilian Miao, Patricia A. Cleary, John M. Lachin, David M. Nathan, Rob J. Van Der Geest, Elsayed Z. Soliman, Chia Ying Liu, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

BACKGROUND-: We report relationships between cardiovascular disease risk factors and myocardial structure, function, and scar in patients with type 1 diabetes mellitus in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. METHODS AND RESULTS-: Cardiac magnetic resonance was obtained in 1017 patients with type 1 diabetes mellitus. Gadolinium cardiac magnetic resonance was also obtained in 741 patients. The mean age was 49±7 years; 52% were men; and mean duration of diabetes mellitus was 28±5 years. Associations of cardiovascular disease risk factors with cardiac magnetic resonance parameters were examined with linear and logistic regression models. History of macroalbuminuria was positively associated with left ventricular mass (by 14.8 g), leading to a significantly higher ratio of left ventricular mass to end-diastolic volume (by 8%). Mean hemoglobin A1c levels over the preceding 22 years were inversely associated with end-diastolic volume (-3.0 mL per unit mean hemoglobin A1c percent) and stroke volume (-2.3 mL per unit mean hemoglobin A1c percent) and positively related to the ratio of elevated left ventricular mass to end-diastolic volume (0.02 g/mL per unit). The overall prevalence of myocardial scar was 4.3% by cardiac magnetic resonance and 1.4% by clinical adjudication of myocardial infarction. Both mean hemoglobin A1c (odds ratio, 1.5 [95% confidence interval, 1.0-2.2] per unit) and macroalbuminuria (odds ratio, 3.5 [95% confidence interval, 1.2-9.9]) were significantly associated with myocardial scar and traditional cardiovascular disease risk factors. CONCLUSIONS-: In addition to traditional cardiovascular disease risk factors, elevated mean hemoglobin A1c and macroalbuminuria were significantly associated with alterations in left ventricular structure and function. The prevalence of myocardial scar was 4.3% in this subcohort of DCCT/EDIC participants with relatively preserved renal function.

Original languageEnglish (US)
Pages (from-to)1737-1746
Number of pages10
JournalCirculation
Volume124
Issue number16
DOIs
StatePublished - Oct 18 2011

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Type 1 Diabetes Mellitus
Cicatrix
Diabetes Complications
Hemoglobins
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Epidemiology
Logistic Models
Odds Ratio
Confidence Intervals
Gadolinium
Left Ventricular Function
Stroke Volume
Linear Models
Diabetes Mellitus
Myocardial Infarction
Kidney

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Turkbey, E. B., Backlund, J. Y. C., Genuth, S., Jain, A., Miao, C., Cleary, P. A., ... Bluemke, D. A. (2011). Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation, 124(16), 1737-1746. https://doi.org/10.1161/CIRCULATIONAHA.111.022327

Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. / Turkbey, Evrim B.; Backlund, Jye Yu C; Genuth, Saul; Jain, Aditya; Miao, Cuilian; Cleary, Patricia A.; Lachin, John M.; Nathan, David M.; Van Der Geest, Rob J.; Soliman, Elsayed Z.; Liu, Chia Ying; Lima, Joao; Bluemke, David A.

In: Circulation, Vol. 124, No. 16, 18.10.2011, p. 1737-1746.

Research output: Contribution to journalArticle

Turkbey, EB, Backlund, JYC, Genuth, S, Jain, A, Miao, C, Cleary, PA, Lachin, JM, Nathan, DM, Van Der Geest, RJ, Soliman, EZ, Liu, CY, Lima, J & Bluemke, DA 2011, 'Myocardial structure, function, and scar in patients with type 1 diabetes mellitus', Circulation, vol. 124, no. 16, pp. 1737-1746. https://doi.org/10.1161/CIRCULATIONAHA.111.022327
Turkbey EB, Backlund JYC, Genuth S, Jain A, Miao C, Cleary PA et al. Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation. 2011 Oct 18;124(16):1737-1746. https://doi.org/10.1161/CIRCULATIONAHA.111.022327
Turkbey, Evrim B. ; Backlund, Jye Yu C ; Genuth, Saul ; Jain, Aditya ; Miao, Cuilian ; Cleary, Patricia A. ; Lachin, John M. ; Nathan, David M. ; Van Der Geest, Rob J. ; Soliman, Elsayed Z. ; Liu, Chia Ying ; Lima, Joao ; Bluemke, David A. / Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. In: Circulation. 2011 ; Vol. 124, No. 16. pp. 1737-1746.
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AU - Turkbey, Evrim B.

AU - Backlund, Jye Yu C

AU - Genuth, Saul

AU - Jain, Aditya

AU - Miao, Cuilian

AU - Cleary, Patricia A.

AU - Lachin, John M.

AU - Nathan, David M.

AU - Van Der Geest, Rob J.

AU - Soliman, Elsayed Z.

AU - Liu, Chia Ying

AU - Lima, Joao

AU - Bluemke, David A.

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N2 - BACKGROUND-: We report relationships between cardiovascular disease risk factors and myocardial structure, function, and scar in patients with type 1 diabetes mellitus in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. METHODS AND RESULTS-: Cardiac magnetic resonance was obtained in 1017 patients with type 1 diabetes mellitus. Gadolinium cardiac magnetic resonance was also obtained in 741 patients. The mean age was 49±7 years; 52% were men; and mean duration of diabetes mellitus was 28±5 years. Associations of cardiovascular disease risk factors with cardiac magnetic resonance parameters were examined with linear and logistic regression models. History of macroalbuminuria was positively associated with left ventricular mass (by 14.8 g), leading to a significantly higher ratio of left ventricular mass to end-diastolic volume (by 8%). Mean hemoglobin A1c levels over the preceding 22 years were inversely associated with end-diastolic volume (-3.0 mL per unit mean hemoglobin A1c percent) and stroke volume (-2.3 mL per unit mean hemoglobin A1c percent) and positively related to the ratio of elevated left ventricular mass to end-diastolic volume (0.02 g/mL per unit). The overall prevalence of myocardial scar was 4.3% by cardiac magnetic resonance and 1.4% by clinical adjudication of myocardial infarction. Both mean hemoglobin A1c (odds ratio, 1.5 [95% confidence interval, 1.0-2.2] per unit) and macroalbuminuria (odds ratio, 3.5 [95% confidence interval, 1.2-9.9]) were significantly associated with myocardial scar and traditional cardiovascular disease risk factors. CONCLUSIONS-: In addition to traditional cardiovascular disease risk factors, elevated mean hemoglobin A1c and macroalbuminuria were significantly associated with alterations in left ventricular structure and function. The prevalence of myocardial scar was 4.3% in this subcohort of DCCT/EDIC participants with relatively preserved renal function.

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