Myocardial steatosis and its association with obesity and regional ventricular dysfunction: Evaluated by magnetic resonance tagging and 1H spectroscopy in healthy African Americans

Chia Ying Liu, David A. Bluemke, Gary Gerstenblith, Stefan Zimmerman, Ji Li, Hong Zhu, Shenghan Lai, Hong Chen Lai

Research output: Contribution to journalArticle

Abstract

Background Cardiac steatosis is common in patients with diabetes or obesity, and cardiac steatosis may result in cardiomyopathy. However, factors associated with cardiac steatosis have not been reported in healthy individuals without diabetes and hypertension. The objectives of this study were to explore factors associated with myocardial triglyceride levels, and to examine the association between myocardial triglyceride and regional left ventricular (LV) function in healthy African Americans (AAs). Methods Between November 2010 and June 2012, 92 healthy AAs aged 21 years or older, without clinical evidence of cardiac dysfunction, coronary artery disease, diabetes, or hypertension from Baltimore, Maryland, were enrolled in an observational proton magnetic resonance spectroscopy and imaging study investigating factors associated with cardiac steatosis, and the relationships between cardiac steatosis and LV volumes and LV function. Results Among the participants, all had a low Framingham risk; 31 had a normal BMI, 23 were overweight and 38 were obese. The median myocardial triglyceride content was 0.5% (IQR: 0.3-1.0%). Among the factors investigated, BMI (R2 = 0.43, p = <0.0001) was independently associated with myocardial triglyceride. Overall, myocardial triglyceride was not associated with LV EF/structure, but may be associated with regional LV function. Conclusions In healthy AA adults, obesity is associated with cardiac steatosis. In contrast to studies in patients with diabetes suggesting a link between cardiac steatosis and LV dysfunction, this study found no relationship between cardiac steatosis and left ventricular volumes or EF, though there is some evidence suggesting that cardiac steatosis may be associated with LV regional function in healthy AA women.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalInternational Journal of Cardiology
Volume172
Issue number2
DOIs
StatePublished - Mar 15 2014

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Ventricular Dysfunction
African Americans
Spectrum Analysis
Triglycerides
Magnetic Resonance Spectroscopy
Left Ventricular Function
Obesity
Hypertension
Baltimore
Left Ventricular Dysfunction
Cardiomyopathies
Coronary Artery Disease
Magnetic Resonance Imaging

Keywords

  • African Americans
  • Cardiac steatosis
  • LV regional function
  • MR spectroscopy
  • MR tagging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

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title = "Myocardial steatosis and its association with obesity and regional ventricular dysfunction: Evaluated by magnetic resonance tagging and 1H spectroscopy in healthy African Americans",
abstract = "Background Cardiac steatosis is common in patients with diabetes or obesity, and cardiac steatosis may result in cardiomyopathy. However, factors associated with cardiac steatosis have not been reported in healthy individuals without diabetes and hypertension. The objectives of this study were to explore factors associated with myocardial triglyceride levels, and to examine the association between myocardial triglyceride and regional left ventricular (LV) function in healthy African Americans (AAs). Methods Between November 2010 and June 2012, 92 healthy AAs aged 21 years or older, without clinical evidence of cardiac dysfunction, coronary artery disease, diabetes, or hypertension from Baltimore, Maryland, were enrolled in an observational proton magnetic resonance spectroscopy and imaging study investigating factors associated with cardiac steatosis, and the relationships between cardiac steatosis and LV volumes and LV function. Results Among the participants, all had a low Framingham risk; 31 had a normal BMI, 23 were overweight and 38 were obese. The median myocardial triglyceride content was 0.5{\%} (IQR: 0.3-1.0{\%}). Among the factors investigated, BMI (R2 = 0.43, p = <0.0001) was independently associated with myocardial triglyceride. Overall, myocardial triglyceride was not associated with LV EF/structure, but may be associated with regional LV function. Conclusions In healthy AA adults, obesity is associated with cardiac steatosis. In contrast to studies in patients with diabetes suggesting a link between cardiac steatosis and LV dysfunction, this study found no relationship between cardiac steatosis and left ventricular volumes or EF, though there is some evidence suggesting that cardiac steatosis may be associated with LV regional function in healthy AA women.",
keywords = "African Americans, Cardiac steatosis, LV regional function, MR spectroscopy, MR tagging",
author = "Liu, {Chia Ying} and Bluemke, {David A.} and Gary Gerstenblith and Stefan Zimmerman and Ji Li and Hong Zhu and Shenghan Lai and Lai, {Hong Chen}",
year = "2014",
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T1 - Myocardial steatosis and its association with obesity and regional ventricular dysfunction

T2 - Evaluated by magnetic resonance tagging and 1H spectroscopy in healthy African Americans

AU - Liu, Chia Ying

AU - Bluemke, David A.

AU - Gerstenblith, Gary

AU - Zimmerman, Stefan

AU - Li, Ji

AU - Zhu, Hong

AU - Lai, Shenghan

AU - Lai, Hong Chen

PY - 2014/3/15

Y1 - 2014/3/15

N2 - Background Cardiac steatosis is common in patients with diabetes or obesity, and cardiac steatosis may result in cardiomyopathy. However, factors associated with cardiac steatosis have not been reported in healthy individuals without diabetes and hypertension. The objectives of this study were to explore factors associated with myocardial triglyceride levels, and to examine the association between myocardial triglyceride and regional left ventricular (LV) function in healthy African Americans (AAs). Methods Between November 2010 and June 2012, 92 healthy AAs aged 21 years or older, without clinical evidence of cardiac dysfunction, coronary artery disease, diabetes, or hypertension from Baltimore, Maryland, were enrolled in an observational proton magnetic resonance spectroscopy and imaging study investigating factors associated with cardiac steatosis, and the relationships between cardiac steatosis and LV volumes and LV function. Results Among the participants, all had a low Framingham risk; 31 had a normal BMI, 23 were overweight and 38 were obese. The median myocardial triglyceride content was 0.5% (IQR: 0.3-1.0%). Among the factors investigated, BMI (R2 = 0.43, p = <0.0001) was independently associated with myocardial triglyceride. Overall, myocardial triglyceride was not associated with LV EF/structure, but may be associated with regional LV function. Conclusions In healthy AA adults, obesity is associated with cardiac steatosis. In contrast to studies in patients with diabetes suggesting a link between cardiac steatosis and LV dysfunction, this study found no relationship between cardiac steatosis and left ventricular volumes or EF, though there is some evidence suggesting that cardiac steatosis may be associated with LV regional function in healthy AA women.

AB - Background Cardiac steatosis is common in patients with diabetes or obesity, and cardiac steatosis may result in cardiomyopathy. However, factors associated with cardiac steatosis have not been reported in healthy individuals without diabetes and hypertension. The objectives of this study were to explore factors associated with myocardial triglyceride levels, and to examine the association between myocardial triglyceride and regional left ventricular (LV) function in healthy African Americans (AAs). Methods Between November 2010 and June 2012, 92 healthy AAs aged 21 years or older, without clinical evidence of cardiac dysfunction, coronary artery disease, diabetes, or hypertension from Baltimore, Maryland, were enrolled in an observational proton magnetic resonance spectroscopy and imaging study investigating factors associated with cardiac steatosis, and the relationships between cardiac steatosis and LV volumes and LV function. Results Among the participants, all had a low Framingham risk; 31 had a normal BMI, 23 were overweight and 38 were obese. The median myocardial triglyceride content was 0.5% (IQR: 0.3-1.0%). Among the factors investigated, BMI (R2 = 0.43, p = <0.0001) was independently associated with myocardial triglyceride. Overall, myocardial triglyceride was not associated with LV EF/structure, but may be associated with regional LV function. Conclusions In healthy AA adults, obesity is associated with cardiac steatosis. In contrast to studies in patients with diabetes suggesting a link between cardiac steatosis and LV dysfunction, this study found no relationship between cardiac steatosis and left ventricular volumes or EF, though there is some evidence suggesting that cardiac steatosis may be associated with LV regional function in healthy AA women.

KW - African Americans

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KW - MR spectroscopy

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