Myocardial reperfusion injury

Role of oxygen radicals and potential therapy with antioxidants

Mohamed O. Jeroudi, Craig J. Hartley, Roberto Bolli

Research output: Contribution to journalArticle

Abstract

Experimental studies have demonstrated that reperfusion is associated with a host of distinctive pathophysiologic derangements, the most important of which are reperfusion arrhythmias, transient mechanical dysfunction or "myocardial stunning," and cell death. Reperfusion arrhythmias and myocardial stunning occur in experimental animals after transient ischemia followed by reperfusion, and there is considerable evidence that these derangements also develop in humans, although the existence of malignant reperfusion arrhythmias in humans remains uncertain. Reperfusion arrhythmias and myocardial stunning can be considered manifestations of sublethal, reversible cellular injury. The pathogenesis of reperfusion arrhythmias and stunning has not been conclusively established; however, there is considerable evidence that generation of oxygen radicals and perturbations of calcium homeostasis play an important role. Antioxidants and calcium antagonists have been shown to mitigate these manifestations of reperfusion injury. In contrast, the likelihood of lethal reperfusion-induced injury remains highly controversial. Although many studies have reported reduction of infarct size with antioxidants, numerous others have failed to reproduce these results. Consequently, intense controversy persists regarding whether oxygen radicals contribute to extending cell death following reperfusion and whether reperfusion itself causes cell death. Neither the resolution of this controversy nor the availability of clinical therapies to reduce reperfusion-induced cell death is likely in the near future.

Original languageEnglish (US)
JournalThe American Journal of Cardiology
Volume73
Issue number6
DOIs
StatePublished - Mar 10 1994
Externally publishedYes

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Myocardial Reperfusion Injury
Reperfusion
Reactive Oxygen Species
Antioxidants
Cardiac Arrhythmias
Myocardial Stunning
Cell Death
Therapeutics
Reperfusion Injury
Calcium
Cause of Death
Homeostasis
Ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial reperfusion injury : Role of oxygen radicals and potential therapy with antioxidants. / Jeroudi, Mohamed O.; Hartley, Craig J.; Bolli, Roberto.

In: The American Journal of Cardiology, Vol. 73, No. 6, 10.03.1994.

Research output: Contribution to journalArticle

Jeroudi, Mohamed O. ; Hartley, Craig J. ; Bolli, Roberto. / Myocardial reperfusion injury : Role of oxygen radicals and potential therapy with antioxidants. In: The American Journal of Cardiology. 1994 ; Vol. 73, No. 6.
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