Myocardial redistribution of technetium-99m-methoxyisobutyl isonitrile (SESTAMIBI)

Q. S. Li, G. Solot, T. L. Frank, H. N. Wagner, Lewis Becker

Research output: Contribution to journalArticle

Abstract

To determine whether technetium-99m-hexakis-2-methoxyisobutyl isonitrile (SESTAMIBI) remains fixed in the myocardium following its initial uptake or undergoes time-related redistribution, anesthetized dogs underwent occlusion of the anterior descending coronary artery for 6 min, followed by 3-hr reperfusion. Technetium-99m-SESTAMIBI and thallium-201 (201Tl) were injected intravenously after 1 min occlusion and regional myocardial blood flow was measured with radioactive microspheres. Tomographic imaging of Tc-SESTAMIBI revealed a perfusion defect with slight but definite filling in over 2 hr. Quantitative analysis indicated a significant rise in the nadir and decrease in the width of the defect in circumferential profile curves. After 3-hr of reperfusion, Tc-SESTAMIBI activity in the previously ischemic area was always greater than the activity of microspheres injected during coronary occlusion (mean normalized values, 0.32 versus 0.11, p <0.0001). Our results indicate that following transient ischemia and reperfusion. Tc-SESTAMIBI clearly undergoes myocardial redistribution, although more slowly and less completely than 201Tl.

Original languageEnglish (US)
Pages (from-to)1069-1076
Number of pages8
JournalJournal of Nuclear Medicine
Volume31
Issue number6
StatePublished - 1990

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Technetium
Reperfusion
Microspheres
Thallium
Coronary Occlusion
Regional Blood Flow
Coronary Vessels
Myocardium
Ischemia
Perfusion
Dogs

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Myocardial redistribution of technetium-99m-methoxyisobutyl isonitrile (SESTAMIBI). / Li, Q. S.; Solot, G.; Frank, T. L.; Wagner, H. N.; Becker, Lewis.

In: Journal of Nuclear Medicine, Vol. 31, No. 6, 1990, p. 1069-1076.

Research output: Contribution to journalArticle

Li, QS, Solot, G, Frank, TL, Wagner, HN & Becker, L 1990, 'Myocardial redistribution of technetium-99m-methoxyisobutyl isonitrile (SESTAMIBI)', Journal of Nuclear Medicine, vol. 31, no. 6, pp. 1069-1076.
Li, Q. S. ; Solot, G. ; Frank, T. L. ; Wagner, H. N. ; Becker, Lewis. / Myocardial redistribution of technetium-99m-methoxyisobutyl isonitrile (SESTAMIBI). In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 6. pp. 1069-1076.
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