Abstract
To determine whether technetium-99m-hexakis-2-methoxyisobutyl isonitrile (SESTAMIBI) remains fixed in the myocardium following its initial uptake or undergoes time-related redistribution, anesthetized dogs underwent occlusion of the anterior descending coronary artery for 6 min, followed by 3-hr reperfusion. Technetium-99m-SESTAMIBI and thallium-201 (201Tl) were injected intravenously after 1 min occlusion and regional myocardial blood flow was measured with radioactive microspheres. Tomographic imaging of Tc-SESTAMIBI revealed a perfusion defect with slight but definite filling in over 2 hr. Quantitative analysis indicated a significant rise in the nadir and decrease in the width of the defect in circumferential profile curves. After 3-hr of reperfusion, Tc-SESTAMIBI activity in the previously ischemic area was always greater than the activity of microspheres injected during coronary occlusion (mean normalized values, 0.32 versus 0.11, p < 0.0001). Our results indicate that following transient ischemia and reperfusion. Tc-SESTAMIBI clearly undergoes myocardial redistribution, although more slowly and less completely than 201Tl.
Original language | English (US) |
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Pages (from-to) | 1069-1076 |
Number of pages | 8 |
Journal | Journal of Nuclear Medicine |
Volume | 31 |
Issue number | 6 |
State | Published - Jan 1 1990 |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging