Abstract
This study examined anatomic differences between the adult and the newborn heart as they relate to myocardial preservation and compared standard techniques of myocardial preservation used in operations for congenital heart disease. The biventricular endocardial surface area/ventricular mass ratios were calculated in 10 neonatal (2.5 ± 0.2:1) and 10 adults (0.6 ± 0.1:1) pigs (p < 0.001). Three groups of neonatal pigs underwent 1 hour of global myocardial ischemia while being supported by cardiopulmonary bypass. Myocardial protection was by deep systemic hypothermia (group 1), moderate systemic hypothermia and cardioplegia (group 2), or by deep systemic hypothermia and cardioplegia (group 3). Left ventricular end-systolic pressure-dimension and end-diastolic pressure-dimension relationships were measured before and after cardiopulmonary bypass. Septal temperatures remained below 20°C in groups 1 and 3 but rose above 20°C in group 2. Groups 1 and 2 had moderate and mild ventricular stiffening respectively, whereas group 3 showed no diastolic dysfunction. Ventricular contractility was increased (p < 0.05) in group 3. Techniques for myocardial preservation used during operations for congenital heart disease must consider the large endocardial surface area/mass ratio and the rewarming effects of systemic blood. The combination of deep systemic hypothermia and cardioplegia provided superior myocardial protection compared with the other techniques tested.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 414-422 |
| Number of pages | 9 |
| Journal | Journal of Thoracic and Cardiovascular Surgery |
| Volume | 96 |
| Issue number | 3 |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Myocardial preservation in the neonate : Beneficial effects of cardioplegia and systemic hypothermia on piglets undergoing cardiopulmonary bypass and myocardial ischemia. / Ganzel, B. L.; Katzmark, S. L.; Mavroudis, Constantine.
In: Journal of Thoracic and Cardiovascular Surgery, Vol. 96, No. 3, 01.01.1988, p. 414-422.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial preservation in the neonate
T2 - Beneficial effects of cardioplegia and systemic hypothermia on piglets undergoing cardiopulmonary bypass and myocardial ischemia
AU - Ganzel, B. L.
AU - Katzmark, S. L.
AU - Mavroudis, Constantine
PY - 1988/1/1
Y1 - 1988/1/1
N2 - This study examined anatomic differences between the adult and the newborn heart as they relate to myocardial preservation and compared standard techniques of myocardial preservation used in operations for congenital heart disease. The biventricular endocardial surface area/ventricular mass ratios were calculated in 10 neonatal (2.5 ± 0.2:1) and 10 adults (0.6 ± 0.1:1) pigs (p < 0.001). Three groups of neonatal pigs underwent 1 hour of global myocardial ischemia while being supported by cardiopulmonary bypass. Myocardial protection was by deep systemic hypothermia (group 1), moderate systemic hypothermia and cardioplegia (group 2), or by deep systemic hypothermia and cardioplegia (group 3). Left ventricular end-systolic pressure-dimension and end-diastolic pressure-dimension relationships were measured before and after cardiopulmonary bypass. Septal temperatures remained below 20°C in groups 1 and 3 but rose above 20°C in group 2. Groups 1 and 2 had moderate and mild ventricular stiffening respectively, whereas group 3 showed no diastolic dysfunction. Ventricular contractility was increased (p < 0.05) in group 3. Techniques for myocardial preservation used during operations for congenital heart disease must consider the large endocardial surface area/mass ratio and the rewarming effects of systemic blood. The combination of deep systemic hypothermia and cardioplegia provided superior myocardial protection compared with the other techniques tested.
AB - This study examined anatomic differences between the adult and the newborn heart as they relate to myocardial preservation and compared standard techniques of myocardial preservation used in operations for congenital heart disease. The biventricular endocardial surface area/ventricular mass ratios were calculated in 10 neonatal (2.5 ± 0.2:1) and 10 adults (0.6 ± 0.1:1) pigs (p < 0.001). Three groups of neonatal pigs underwent 1 hour of global myocardial ischemia while being supported by cardiopulmonary bypass. Myocardial protection was by deep systemic hypothermia (group 1), moderate systemic hypothermia and cardioplegia (group 2), or by deep systemic hypothermia and cardioplegia (group 3). Left ventricular end-systolic pressure-dimension and end-diastolic pressure-dimension relationships were measured before and after cardiopulmonary bypass. Septal temperatures remained below 20°C in groups 1 and 3 but rose above 20°C in group 2. Groups 1 and 2 had moderate and mild ventricular stiffening respectively, whereas group 3 showed no diastolic dysfunction. Ventricular contractility was increased (p < 0.05) in group 3. Techniques for myocardial preservation used during operations for congenital heart disease must consider the large endocardial surface area/mass ratio and the rewarming effects of systemic blood. The combination of deep systemic hypothermia and cardioplegia provided superior myocardial protection compared with the other techniques tested.
UR - http://www.scopus.com/inward/record.url?scp=0023711075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023711075&partnerID=8YFLogxK
M3 - Article
C2 - 3411986
AN - SCOPUS:0023711075
VL - 96
SP - 414
EP - 422
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 3
ER -