Myocardial perfusion with [11C]metbyl triphenyl phosphonium: Measurements of the extraction fraction and myocardial uptake

B. J. Krause, Z. Szabo, L. C. Becker, R. F. Dannals, U. Scheffel, C. Seki, H. T. Ravert, A. F. Dipaola, H. N. Wagner

Research output: Contribution to journalArticlepeer-review

Abstract

The present study describes extraction fraction and uptake measurements of the [11C]methyl triphenyl phosphonium (11C-MTP), a promising positron emission tomography (PET) agent for cardiac imaging. PET imaging was Performed in mongrel dogs. Under physiological flow conditions 11C-MTP uptake reached a maximum within the first 10 minutes after injection and remained constant during the entire observation period of 80 minutes. Over the same time period, the heartlblood ratio was 46 - 106:1, and the heart/lung ratio 14:1. following permanent occlusion of the left anterior descending coronary artery, 11C-MTP uptake in the normally perfused myocardium also reached a maximum at 10 minutes after injection, whereas in the infarcted area there was no significant accumulation of 11C-MTP. For a time period of 80 minutes the noninfarcted/infarcted myocardium ratio was 12:1. Extraction was measured in anesthetized dogs with a double isotope method using 99mTc-HSA as the reference tracer. The extraction fraction was 91% at a flow of 69 mL/min/100g. As flow increased to five-fold (342 mL/min/100g) following administration of adenosine, extraction fell to 61%. Following coronary artery occlusion, the 11C-MTP content in the myocardium was highly correlated (r = 0.93, p < 0.01; y = 10.46 + 0.92x) with the microsphere determined regional myocardial blood flow.

Original languageEnglish (US)
Pages (from-to)521-526
Number of pages6
JournalJournal of Nuclear Biology and Medicine
Volume38
Issue number3
StatePublished - 1994

Keywords

  • Extraction fraction
  • Mayocardial uptake
  • PET cardiac imaging
  • [C]methyl triphenyl phosphonium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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