@article{c3b00b6d04424e9c8e94c9abdb7b2b04,
title = "Myocardial perfusion SPECT using a rotating multi-segment slant-hole collimator",
abstract = "Purpose: A rotating multi-segment slant-hole (RMSSH) collimator is able to provide much higher (∼3 times for four-segment collimator with 30° slant angle) sensitivity than a parallel-hole (PH) collimator with the similar spatial resolution for imaging small organs such as the heart and the breast. In this article, the authors evaluated the performance of myocardial perfusion SPECT (MPS) using a RMSSH collimator compared to MPS using the low-energy high-resolution parallel-hole collimators. Methods: The authors conducted computer simulation studies using the NURBS-based cardiac-torso phantom, receiver operative characteristic (ROC) analysis using the channelized Hotelling observer, physical phantom experiments, and pilot patient studies to evaluate the performance of MPS using a rotating four-segment slant-hole (R4SSH) collimator with respect to MPS using a PH collimator. Results: In the simulation study, the R4SSH MPS provides images with superior contrast-noise trade-off than those of PH MPS with the same acquisition time. The defect detectability in terms of the largest area under the ROC curve for R4SSH MPS is significantly higher than those of PH MPS with p -values <0.01. In the phantom experiments, the R4SSH MPS images with 7.5 min acquisition had similar noise level and overall image quality as those of PH MPS with 21 min acquisition. Pilot patient studies showed that with the same acquisition time, the R4SSH SPECT using a single-head camera gave images with similar quality as those of PH SPECT using a dual-head camera. Conclusions: The RMSSH SPECT has a potential to improve the coronary artery disease detection and workflow of SPECT imaging acquisition due to the high sensitivity property of the RMSSH collimator.",
keywords = "Myocardial perfusion SPECT, Parallel-hole collimator, Rotating multisegment slant-hole collimator",
author = "Chi Liu and Jingyan Xu and Tsui, {Benjamin M.W.}",
note = "Funding Information: This work is supported by the National Institutes of Health under Grant No. R01-EB001983. The authors thank Philips Medical System for the technical support of the Precedence {\textregistered} SPECT/CT system and list-mode acquisition. Thanks also go to Eric Frey, Xin He, and Yuchuan Wang for helpful discussions; Si Chen for writing the motor control program; Xiaolan Wang for help with reslicing the cardiac images; Linda Wilkins and Susanne Bonekamp for coordinating patient studies; and Erico Blomer for his help with installing the R4SSH collimator onto the Precedence {\textregistered} system and other scanner-related problems in the studies. TABLE I. Collimator parameters of the R4SSH and GE LEHR collimator used in simulation. R4SSH GE LEHR Hole size (cm) 0.19 0.15 Hole length (cm) 5.93 3.5 Slant angle (deg) 32.5 ⋯ Collimator thickness (cm) 5.00 3.5 Distance from the collimator face to the CVOV center (cm) 14.45 ⋯ Diameter of the CVOV (cm) 11.87 ⋯ Average collimator resolution at 14.45 cm (cm) 0.81 0.77 Sensitivity ( × 10 − 3 ) 0.17 0.07 TABLE II. Test for statistical significance between different imaging methods with highest AUC using optimized parameters. Method 1 Method 2 AUC mean for Method 1 AUC standard deviation for Method 1 AUC mean for Method 2 AUC standard deviation for Method 2 p -value Statistically significant PH w/o AC R4SSH w/o AC 0.817 0.042 0.943 0.022 0.0031 Yes PH w/AC R4SSH w/AC 0.839 0.039 0.971 0.014 0.0019 Yes PH w/o AC PH w/AC 0.817 0.042 0.839 0.039 0.3460 No R4SSH w/o AC R4SSH w/AC 0.943 0.022 0.971 0.014 0.1048 No TABLE III. Patient characteristics. Patient index Gender Weight(lbs) 1 Female 212 2 Male 250 3 Male 157 4 Female N/A a 5 Male 167 a The acquisition failed at the beginning, therefore this patient was not included in the data analysis and no weight information can be retrieved. FIG. 1. (a) Cross-sectional view through the center of a R4SSH collimator. (b) Configuration of acquisition geometry with three camera positions for RMSSH myocardial SPECT. (c) Sample projections of a R4SSH cardiac SPECT patient study. FIG. 2. (a) The R4SSH collimator with rotating motor mounted on the Philips Precedence {\textregistered} SPECT/CT system. (b) The data spectrum{\textquoteright}s anthropomorphic torso phantom with heart insert. FIG. 3. (a) Sample short-axis slices of PH and R4SSH SPECT noisy images reconstructed with and without AC for different iterations. Images were reconstructed using OS-EM algorithm with four subsets and no postfiltering was applied. (b) Image noise level as a function of defect contrast for PH and R4SSH SPECT without and with AC for different iterations. FIG. 4. (a) AUC as a function of cutoff frequencies for R4SSH and PH SPECT with the optimized number of iterations. (b) AUC as a function of number of iterations for R4SSH and PH SPECT with the optimized cutoff frequencies. (c) Highest AUCs with standard deviations for R4SSH and PH SPECT without and with AC. FIG. 5. Sample reconstructed slices of PH and R4SSH SEPCT with different acquisition times in the phantom experiment. No postfiltering was applied. FIG. 6. Sample PH and R4SSH SPECT reconstructed horizontal long axis slices of the first patient study. Both images were reconstructed with the compensations of attenuation, scatter, and collimator-detector response. No postfiltering was applied. PH images are at the fifth iteration with four subsets (20 updates). R4SSH images are at the fourth iteration with five subsets (20 updates). FIG. 7. Sample R4SSH SPECT reconstructed transaxial slices (without postfiltering) of the second patient study, which failed to center the heart in the CVOV due to the patient size. ",
year = "2010",
doi = "10.1118/1.3310386",
language = "English (US)",
volume = "37",
pages = "1610--1618",
journal = "Medical physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "4",
}