Myocardial perfusion imaging for predicting cardiac events in Japanese patients with advanced chronic kidney disease: 1-year interim report of the J-ACCESS 3 investigation

Nobuhiko Joki, Hiroki Hase, Yuhei Kawano, Satoko Nakamura, Kenichi Nakajima, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Shunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Purpose: Whether myocardial perfusion imaging (MPI) can predict cardiac events in patients with advanced conservative chronic kidney disease (CKD) remains unclear. Methods: The present multicenter prospective cohort study aimed to clarify the ability of MPI to predict cardiac events in 529 patients with CKD and estimated glomerular filtration rates (eGFR)<50 ml/min per 1.73 2 without a definitive diagnosis of coronary artery disease. All patients were assessed by stress-rest MPI with 99mTc-tetrofosmin and analyzed using summed defect scores and QGS software. Cardiac events were analyzed 1 year after registration. Results: Myocardial perfusion abnormalities defined as summed stress score (SSS) ≥4 and ≥8 were identified in 19 and 7 % of patients, respectively. At the end of the 1-year follow-up, 33 (6.2 %) cardiac events had occurred that included cardiac death, sudden death, nonfatal myocardial infarction, and hospitalization due to heart failure. The event-free rates at that time were 0.95, 0.90, and 0.81 for groups with SSS 0-3, 4-7, and ≥8, respectively (p=0.0009). Thus, patients with abnormal SSS had a higher incidence of cardiac events. Multivariate Cox regression analysis showed that SSS significantly impacts the prediction of cardiac events independently of eGFR and left ventricular ejection fraction. Conclusion: MPI would be useful to stratify patients with advanced conservative CKD who are at high risk of cardiac events without adversely affecting damaged kidneys.

Original languageEnglish (US)
Pages (from-to)1701-1709
Number of pages9
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume41
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Chronic kidney disease
  • Coronary artery disease
  • Hemoglobin
  • Multicenter study

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Joki, N., Hase, H., Kawano, Y., Nakamura, S., Nakajima, K., Hatta, T., Nishimura, S., Moroi, M., Nakagawa, S., Kasai, T., Kusuoka, H., Takeishi, Y., Momose, M., Takehana, K., Nanasato, M., Yoda, S., Nishina, H., Matsumoto, N., & Nishimura, T. (2014). Myocardial perfusion imaging for predicting cardiac events in Japanese patients with advanced chronic kidney disease: 1-year interim report of the J-ACCESS 3 investigation. European Journal of Nuclear Medicine and Molecular Imaging, 41(9), 1701-1709. https://doi.org/10.1007/s00259-014-2781-z