Myocardial perfusion imaging based on the blood oxygen level-dependent effect using T2-prepared steady-state free-precession magnetic resonance imaging

David S. Fieno, Steven M. Shea, Yongzhong Li, Kathleen R. Harris, J. Paul Finn, Debiao Li

Research output: Contribution to journalArticlepeer-review


Background-The decision to perform coronary revascularization procedures may hinge on assessment of myocardial perfusion reserve. Blood oxygen level-dependent (BOLD) MRI is a potential method to detect the effects of regional variations in myocardial blood flow during vasodilation. Methods and Results-We imaged dogs (n=13) on a 1.5-T whole-body MRI scanner using a new T2-prepared steady-state free-precession (SSFP) MRI pulse sequence sensitive to BOLD contrast. Images (in-plane resolution ≈1 mm2) of 5 short-axis and 2 long-axis slices of the heart were acquired during graded levels of adenosine infusion via a surgically placed left circumflex (LCx) catheter (n=11) or via a right atrial catheter in animals with an LCx occluder (n=2). Relative myocardial perfusion was measured with the use of fluorescent microspheres. Signal intensity changes in myocardium subtended by the left anterior descending coronary artery were compared with those in the LCx region. Unprocessed T2-weighted images revealed changes in signal intensity corresponding to areas of regional vasodilation or reduced myocardial perfusion reserve during systemic vasodilation. At maximal vasodilation, the signal intensity ratio in the LCx versus left anterior descending territories increased by 33±4% compared with baseline, corresponding to a 3.8±0.3-fold increase in relative perfusion (P<0.01). MR intensity at progressive levels of vasodilation demonstrated good agreement with microsphere flow (R=0.80, P<0.01). Conclusions-T2-prepared SSFP BOLD imaging is a promising method to determine an index of myocardial perfusion reserve in this animal model.

Original languageEnglish (US)
Pages (from-to)1284-1290
Number of pages7
Issue number10
StatePublished - Sep 7 2004


  • Coronary disease
  • Magnetic resonance imaging
  • Myocardium
  • Perfusion
  • Vasodilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Myocardial perfusion imaging based on the blood oxygen level-dependent effect using T<sub>2</sub>-prepared steady-state free-precession magnetic resonance imaging'. Together they form a unique fingerprint.

Cite this