Abstract
To elucidate the metabolism of free fatty acid in the myocardium of hypertrophic cardiomyopathy (HCM), SPET was performed with123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), an analogue of free fatty acid, and with201TI in nine patients with HCM and eight healthy volunteers who acted as controls. For quantitative analysis of the apical area, a radial long-axis tomogram was reconstructed every 6° after short-axis tomography. The relative regional uptake (RRU, %) in each segment was obtained by normalizing to the maximal value among all segments. The 3-h washout rate was calculated both for BMIPP and for201TI. The ratio of the RRU of BMIPP to that of201TI was significantly lower in the apical and antero-septal regions compared with other walls (P201TI in the controls was homogeneous and there was a significant correlation between them. The coefficient of variation (CV) in all segments in the HCM patients was significantly higher (P201TI, indicating inhomogeneous uptake of BMIPP in the HCM patients. The washout rate of BMIPP over 3 h was significantly higher in the patients with HCM (mean ± S.D. 26.3 ± 7.3%) than the controls (18.3 ± 7.5%, P201TI in the HCM patients was increased, especially in the septum and apex. These results indicate that the discordance between blood flow and metabolism in the myocardium, and the abnormal myocardial fatty acid metabolism in HCM patients, involve not only hypertrophic myocardium but also the areas of myocardium adjusting to the hypertrophic regions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 336-343 |
| Number of pages | 8 |
| Journal | Nuclear Medicine Communications |
| Volume | 16 |
| Issue number | 5 |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Myocardial metabolism of123I-BMIPP in patients with hypertrophic cardiomyopathy : Assessment by radial long-axis SPET. / Chen, S. L.; Uehara, T.; Morozumi, T.; Yamagami, H.; Kusuoka, H.; Nishimura, T.
In: Nuclear Medicine Communications, Vol. 16, No. 5, 1995, p. 336-343.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial metabolism of123I-BMIPP in patients with hypertrophic cardiomyopathy
T2 - Assessment by radial long-axis SPET
AU - Chen, S. L.
AU - Uehara, T.
AU - Morozumi, T.
AU - Yamagami, H.
AU - Kusuoka, H.
AU - Nishimura, T.
PY - 1995
Y1 - 1995
N2 - To elucidate the metabolism of free fatty acid in the myocardium of hypertrophic cardiomyopathy (HCM), SPET was performed with123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), an analogue of free fatty acid, and with201TI in nine patients with HCM and eight healthy volunteers who acted as controls. For quantitative analysis of the apical area, a radial long-axis tomogram was reconstructed every 6° after short-axis tomography. The relative regional uptake (RRU, %) in each segment was obtained by normalizing to the maximal value among all segments. The 3-h washout rate was calculated both for BMIPP and for201TI. The ratio of the RRU of BMIPP to that of201TI was significantly lower in the apical and antero-septal regions compared with other walls (P201TI in the controls was homogeneous and there was a significant correlation between them. The coefficient of variation (CV) in all segments in the HCM patients was significantly higher (P201TI, indicating inhomogeneous uptake of BMIPP in the HCM patients. The washout rate of BMIPP over 3 h was significantly higher in the patients with HCM (mean ± S.D. 26.3 ± 7.3%) than the controls (18.3 ± 7.5%, P201TI in the HCM patients was increased, especially in the septum and apex. These results indicate that the discordance between blood flow and metabolism in the myocardium, and the abnormal myocardial fatty acid metabolism in HCM patients, involve not only hypertrophic myocardium but also the areas of myocardium adjusting to the hypertrophic regions.
AB - To elucidate the metabolism of free fatty acid in the myocardium of hypertrophic cardiomyopathy (HCM), SPET was performed with123I-15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), an analogue of free fatty acid, and with201TI in nine patients with HCM and eight healthy volunteers who acted as controls. For quantitative analysis of the apical area, a radial long-axis tomogram was reconstructed every 6° after short-axis tomography. The relative regional uptake (RRU, %) in each segment was obtained by normalizing to the maximal value among all segments. The 3-h washout rate was calculated both for BMIPP and for201TI. The ratio of the RRU of BMIPP to that of201TI was significantly lower in the apical and antero-septal regions compared with other walls (P201TI in the controls was homogeneous and there was a significant correlation between them. The coefficient of variation (CV) in all segments in the HCM patients was significantly higher (P201TI, indicating inhomogeneous uptake of BMIPP in the HCM patients. The washout rate of BMIPP over 3 h was significantly higher in the patients with HCM (mean ± S.D. 26.3 ± 7.3%) than the controls (18.3 ± 7.5%, P201TI in the HCM patients was increased, especially in the septum and apex. These results indicate that the discordance between blood flow and metabolism in the myocardium, and the abnormal myocardial fatty acid metabolism in HCM patients, involve not only hypertrophic myocardium but also the areas of myocardium adjusting to the hypertrophic regions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028990180&partnerID=8YFLogxK
M3 - Article
C2 - 7659385
AN - SCOPUS:0028990180
VL - 16
SP - 336
EP - 343
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
SN - 0143-3636
IS - 5
ER -