Myocardial mechanics and coronary flow dynamics

R. Beyar, D. Manor, S. Sideman, W. Welkowitz, R. Mates

Research output: Contribution to journalArticle

Abstract

The interaction between cardiac mechanics and coronary flow is highlighted here. Left ventricular (LV) structure and geometry are related to coronary flow dynamics and used in the analysis of experimental coronary flow data. The important role of the collagen mesh in the generation of the intramyocardial pressure (IMP), the pressure in the interstitial fluid, at a wide range of loading conditions is emphasized. The calculated IMP, based on a structural model of the LV myocardium, can explain most of the observed coronary compression characteristics under a variety of loading and contractility conditions. A more general compression function, the extravascular compressive pressure (ECP), is suggested to define coronary compression and is presented here based on the dynamics of the coronary inflow under constant perfusion conditions. Coronary compression is shown to be affected by fluid transport and the bi-directional coupling of coronary hemodynamics and IMP dynamics.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalAdvances in Experimental Medicine and Biology
Volume346
StatePublished - 1993
Externally publishedYes

Fingerprint

Mechanics
Pressure
Compaction
Fluids
Structural Models
Extracellular Fluid
Hemodynamics
Myocardium
Collagen
Perfusion
Geometry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Beyar, R., Manor, D., Sideman, S., Welkowitz, W., & Mates, R. (1993). Myocardial mechanics and coronary flow dynamics. Advances in Experimental Medicine and Biology, 346, 125-136.

Myocardial mechanics and coronary flow dynamics. / Beyar, R.; Manor, D.; Sideman, S.; Welkowitz, W.; Mates, R.

In: Advances in Experimental Medicine and Biology, Vol. 346, 1993, p. 125-136.

Research output: Contribution to journalArticle

Beyar, R, Manor, D, Sideman, S, Welkowitz, W & Mates, R 1993, 'Myocardial mechanics and coronary flow dynamics', Advances in Experimental Medicine and Biology, vol. 346, pp. 125-136.
Beyar R, Manor D, Sideman S, Welkowitz W, Mates R. Myocardial mechanics and coronary flow dynamics. Advances in Experimental Medicine and Biology. 1993;346:125-136.
Beyar, R. ; Manor, D. ; Sideman, S. ; Welkowitz, W. ; Mates, R. / Myocardial mechanics and coronary flow dynamics. In: Advances in Experimental Medicine and Biology. 1993 ; Vol. 346. pp. 125-136.
@article{406bd439e2094abcb5e37c1a92c0c24d,
title = "Myocardial mechanics and coronary flow dynamics",
abstract = "The interaction between cardiac mechanics and coronary flow is highlighted here. Left ventricular (LV) structure and geometry are related to coronary flow dynamics and used in the analysis of experimental coronary flow data. The important role of the collagen mesh in the generation of the intramyocardial pressure (IMP), the pressure in the interstitial fluid, at a wide range of loading conditions is emphasized. The calculated IMP, based on a structural model of the LV myocardium, can explain most of the observed coronary compression characteristics under a variety of loading and contractility conditions. A more general compression function, the extravascular compressive pressure (ECP), is suggested to define coronary compression and is presented here based on the dynamics of the coronary inflow under constant perfusion conditions. Coronary compression is shown to be affected by fluid transport and the bi-directional coupling of coronary hemodynamics and IMP dynamics.",
author = "R. Beyar and D. Manor and S. Sideman and W. Welkowitz and R. Mates",
year = "1993",
language = "English (US)",
volume = "346",
pages = "125--136",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

TY - JOUR

T1 - Myocardial mechanics and coronary flow dynamics

AU - Beyar, R.

AU - Manor, D.

AU - Sideman, S.

AU - Welkowitz, W.

AU - Mates, R.

PY - 1993

Y1 - 1993

N2 - The interaction between cardiac mechanics and coronary flow is highlighted here. Left ventricular (LV) structure and geometry are related to coronary flow dynamics and used in the analysis of experimental coronary flow data. The important role of the collagen mesh in the generation of the intramyocardial pressure (IMP), the pressure in the interstitial fluid, at a wide range of loading conditions is emphasized. The calculated IMP, based on a structural model of the LV myocardium, can explain most of the observed coronary compression characteristics under a variety of loading and contractility conditions. A more general compression function, the extravascular compressive pressure (ECP), is suggested to define coronary compression and is presented here based on the dynamics of the coronary inflow under constant perfusion conditions. Coronary compression is shown to be affected by fluid transport and the bi-directional coupling of coronary hemodynamics and IMP dynamics.

AB - The interaction between cardiac mechanics and coronary flow is highlighted here. Left ventricular (LV) structure and geometry are related to coronary flow dynamics and used in the analysis of experimental coronary flow data. The important role of the collagen mesh in the generation of the intramyocardial pressure (IMP), the pressure in the interstitial fluid, at a wide range of loading conditions is emphasized. The calculated IMP, based on a structural model of the LV myocardium, can explain most of the observed coronary compression characteristics under a variety of loading and contractility conditions. A more general compression function, the extravascular compressive pressure (ECP), is suggested to define coronary compression and is presented here based on the dynamics of the coronary inflow under constant perfusion conditions. Coronary compression is shown to be affected by fluid transport and the bi-directional coupling of coronary hemodynamics and IMP dynamics.

UR - http://www.scopus.com/inward/record.url?scp=0027754794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027754794&partnerID=8YFLogxK

M3 - Article

C2 - 8184751

AN - SCOPUS:0027754794

VL - 346

SP - 125

EP - 136

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -