Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy

Afonso Akio Shiozaki, Tiago Senra, Edmundo Arteaga, Martino Martinelli Filho, Cristiane Guedes Pita, Luis Francisco R Ávila, José Rodrigues Parga Filho, Charles Mady, Roberto Kalil-Filho, David A. Bluemke, Carlos Eduardo Rochitte

Research output: Contribution to journalArticle

Abstract

Background: Myocardial fibrosis (MF) occurs in up to 80% of subjects with asymptomatic or mildly symptomatic hypertrophic cardiomyopathy (HCM) and can constitute an arrhythmogenic substrate for re-entrant, life-threatening ventricular arrhythmias in predisposed persons. Objective: The aim was to investigate whether MF detected by delayed enhancement cardiac CT is predictive of ventricular tachycardia (VT) and fibrillation (VF) that require appropriate therapy by an implantable cardioverter defibrillator (ICD) in patients with HCM. Methods: Twenty-six patients with HCM with previously (for at least 1 year) implanted ICD underwent MF evaluation by cardiac CT. MF was quantified by myocardial delayed enhanced cardiac CT. Data on ICD firing were recorded every 3 months after ICD implantation. Risk factors for sudden cardiac death in patients with HCM were evaluated in all patients. Results: MF was present in 25 of 26 patients (96%) with mean fibrosis mass of 20.5 ± 15.8 g. Patients with appropriate ICD shocks for VF/VT had significantly greater MF mass than patients without (29.10 ± 19.13 g vs 13.57 ± 8.31 g; P= .01). For a MF mass of at least 18 g, sensitivity and specificity for appropriate ICD firing were 73% (95% CI, 49%-88%) and 71% (95% CI, 56%-81%), respectively. Kaplan-Meier curves indicated a significantly greater VF/VT event rate in patients with MF mass ≥18 g than in patients with MF

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalJournal of Cardiovascular Computed Tomography
Volume7
Issue number3
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Hypertrophic Cardiomyopathy
Ventricular Fibrillation
Ventricular Tachycardia
Fibrosis
Implantable Defibrillators
Sudden Cardiac Death
Cardiac Arrhythmias
Shock
Sensitivity and Specificity

Keywords

  • Delayed enhancement cardiac computed tomography
  • Hypertrophic cardiomyopathy
  • Implantable cardiac defibrillator
  • Myocardial fibrosis
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy. / Shiozaki, Afonso Akio; Senra, Tiago; Arteaga, Edmundo; Martinelli Filho, Martino; Pita, Cristiane Guedes; Ávila, Luis Francisco R; Parga Filho, José Rodrigues; Mady, Charles; Kalil-Filho, Roberto; Bluemke, David A.; Rochitte, Carlos Eduardo.

In: Journal of Cardiovascular Computed Tomography, Vol. 7, No. 3, 05.2013, p. 173-181.

Research output: Contribution to journalArticle

Shiozaki, AA, Senra, T, Arteaga, E, Martinelli Filho, M, Pita, CG, Ávila, LFR, Parga Filho, JR, Mady, C, Kalil-Filho, R, Bluemke, DA & Rochitte, CE 2013, 'Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy', Journal of Cardiovascular Computed Tomography, vol. 7, no. 3, pp. 173-181. https://doi.org/10.1016/j.jcct.2013.04.002
Shiozaki, Afonso Akio ; Senra, Tiago ; Arteaga, Edmundo ; Martinelli Filho, Martino ; Pita, Cristiane Guedes ; Ávila, Luis Francisco R ; Parga Filho, José Rodrigues ; Mady, Charles ; Kalil-Filho, Roberto ; Bluemke, David A. ; Rochitte, Carlos Eduardo. / Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy. In: Journal of Cardiovascular Computed Tomography. 2013 ; Vol. 7, No. 3. pp. 173-181.
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abstract = "Background: Myocardial fibrosis (MF) occurs in up to 80{\%} of subjects with asymptomatic or mildly symptomatic hypertrophic cardiomyopathy (HCM) and can constitute an arrhythmogenic substrate for re-entrant, life-threatening ventricular arrhythmias in predisposed persons. Objective: The aim was to investigate whether MF detected by delayed enhancement cardiac CT is predictive of ventricular tachycardia (VT) and fibrillation (VF) that require appropriate therapy by an implantable cardioverter defibrillator (ICD) in patients with HCM. Methods: Twenty-six patients with HCM with previously (for at least 1 year) implanted ICD underwent MF evaluation by cardiac CT. MF was quantified by myocardial delayed enhanced cardiac CT. Data on ICD firing were recorded every 3 months after ICD implantation. Risk factors for sudden cardiac death in patients with HCM were evaluated in all patients. Results: MF was present in 25 of 26 patients (96{\%}) with mean fibrosis mass of 20.5 ± 15.8 g. Patients with appropriate ICD shocks for VF/VT had significantly greater MF mass than patients without (29.10 ± 19.13 g vs 13.57 ± 8.31 g; P= .01). For a MF mass of at least 18 g, sensitivity and specificity for appropriate ICD firing were 73{\%} (95{\%} CI, 49{\%}-88{\%}) and 71{\%} (95{\%} CI, 56{\%}-81{\%}), respectively. Kaplan-Meier curves indicated a significantly greater VF/VT event rate in patients with MF mass ≥18 g than in patients with MF",
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T1 - Myocardial fibrosis detected by cardiac CT predicts ventricular fibrillation/ventricular tachycardia events in patients with hypertrophic cardiomyopathy

AU - Shiozaki, Afonso Akio

AU - Senra, Tiago

AU - Arteaga, Edmundo

AU - Martinelli Filho, Martino

AU - Pita, Cristiane Guedes

AU - Ávila, Luis Francisco R

AU - Parga Filho, José Rodrigues

AU - Mady, Charles

AU - Kalil-Filho, Roberto

AU - Bluemke, David A.

AU - Rochitte, Carlos Eduardo

PY - 2013/5

Y1 - 2013/5

N2 - Background: Myocardial fibrosis (MF) occurs in up to 80% of subjects with asymptomatic or mildly symptomatic hypertrophic cardiomyopathy (HCM) and can constitute an arrhythmogenic substrate for re-entrant, life-threatening ventricular arrhythmias in predisposed persons. Objective: The aim was to investigate whether MF detected by delayed enhancement cardiac CT is predictive of ventricular tachycardia (VT) and fibrillation (VF) that require appropriate therapy by an implantable cardioverter defibrillator (ICD) in patients with HCM. Methods: Twenty-six patients with HCM with previously (for at least 1 year) implanted ICD underwent MF evaluation by cardiac CT. MF was quantified by myocardial delayed enhanced cardiac CT. Data on ICD firing were recorded every 3 months after ICD implantation. Risk factors for sudden cardiac death in patients with HCM were evaluated in all patients. Results: MF was present in 25 of 26 patients (96%) with mean fibrosis mass of 20.5 ± 15.8 g. Patients with appropriate ICD shocks for VF/VT had significantly greater MF mass than patients without (29.10 ± 19.13 g vs 13.57 ± 8.31 g; P= .01). For a MF mass of at least 18 g, sensitivity and specificity for appropriate ICD firing were 73% (95% CI, 49%-88%) and 71% (95% CI, 56%-81%), respectively. Kaplan-Meier curves indicated a significantly greater VF/VT event rate in patients with MF mass ≥18 g than in patients with MF

AB - Background: Myocardial fibrosis (MF) occurs in up to 80% of subjects with asymptomatic or mildly symptomatic hypertrophic cardiomyopathy (HCM) and can constitute an arrhythmogenic substrate for re-entrant, life-threatening ventricular arrhythmias in predisposed persons. Objective: The aim was to investigate whether MF detected by delayed enhancement cardiac CT is predictive of ventricular tachycardia (VT) and fibrillation (VF) that require appropriate therapy by an implantable cardioverter defibrillator (ICD) in patients with HCM. Methods: Twenty-six patients with HCM with previously (for at least 1 year) implanted ICD underwent MF evaluation by cardiac CT. MF was quantified by myocardial delayed enhanced cardiac CT. Data on ICD firing were recorded every 3 months after ICD implantation. Risk factors for sudden cardiac death in patients with HCM were evaluated in all patients. Results: MF was present in 25 of 26 patients (96%) with mean fibrosis mass of 20.5 ± 15.8 g. Patients with appropriate ICD shocks for VF/VT had significantly greater MF mass than patients without (29.10 ± 19.13 g vs 13.57 ± 8.31 g; P= .01). For a MF mass of at least 18 g, sensitivity and specificity for appropriate ICD firing were 73% (95% CI, 49%-88%) and 71% (95% CI, 56%-81%), respectively. Kaplan-Meier curves indicated a significantly greater VF/VT event rate in patients with MF mass ≥18 g than in patients with MF

KW - Delayed enhancement cardiac computed tomography

KW - Hypertrophic cardiomyopathy

KW - Implantable cardiac defibrillator

KW - Myocardial fibrosis

KW - Ventricular arrhythmias

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