Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy

Chia Ying Liu, Alban Redheuil, Ronald Ouwerkerk, Joao A.C. Lima, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Proton MR spectroscopy (1H-MRS) has been used for in vivo quantification of intracellular triglycerides within the sarcolemma. The purpose of this study was to assess whether breath-hold dual-echo in- and out-of-phase MRI at 3.0 T can quantify the fat content of the myocardium. Biases, including T1, Tz.ast;2, and noise, that confound the calculation of the fat fraction were carefully corrected. Thirty-four of 46 participants had both MRI and MRS data. The fat fractions from MRI showed a strong correlation with fat fractions from MRS (r = 0.78; P < 0.05). The mean myocardial fat fraction for all 34 subjects was 0.7 ± 0.5% (range: 0.11-3%) assessed with MRS and 1.04 ± 0.4% (range: 0.32-2.44%) assessed with in- and out-of-phase MRI (P < 0.05). Scanning times were less than 15 sec for Dixon imaging, plus an additional minute for the acquisition used for Tz.ast;2 calculation, and 15-20 min for MRS. The average postprocessing time for MRS was 3 min and 5 min for MRI including T z.ast;2 measurement. We conclude that the dual echo method provides a rapid means to detect and quantifying myocardial fat content in vivo. Correction/adjustment for field inhomogeneity using three or more echoes seems crucial for the dual echo approach.

Original languageEnglish (US)
Pages (from-to)892-901
Number of pages10
JournalMagnetic resonance in medicine
Issue number4
StatePublished - May 2010


  • Cardiac steatosis
  • Dixon
  • Magnetic resonance imaging
  • Spectroscopy
  • Water-fat separation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Myocardial fat quantification in humans: Evaluation by two-point water-fat imaging and localized proton spectroscopy'. Together they form a unique fingerprint.

Cite this