TY - JOUR
T1 - Myocardial Dyssynchrony and Resynchronization
AU - Abraham, Theodore P.
AU - Lardo, Albert C.
AU - Kass, David A.
PY - 2006/4
Y1 - 2006/4
N2 - Conduction abnormalities are noted in a number of patients with heart failure and are associated with altered ventricular mechanics (mechanical dyssynchrony), resulting in reduced and inefficient systolic function. Correction of mechanical dyssynchrony via biventricular pacing (cardiac resynchronization) is associated with substantial symptomatic benefits, reverse remodeling of the left ventricle, reduced hospitalizations for heart failure, and improved survival. However, approximately 30% of eligible patients undergoing cardiac resynchronization therapy (CRT) do not experience clinical benefits. This article discusses recent published data that suggest that assessment of mechanical synchrony with echocardiography, especially newer techniques such as tissue Doppler echocardiography (TDE), may be a reliable and accurate means of identifying patients who will best respond to CRT. In addition, MRI provides three-dimensional information on regional mechanics and may emerge as an important technique for assessment of dyssynchrony.
AB - Conduction abnormalities are noted in a number of patients with heart failure and are associated with altered ventricular mechanics (mechanical dyssynchrony), resulting in reduced and inefficient systolic function. Correction of mechanical dyssynchrony via biventricular pacing (cardiac resynchronization) is associated with substantial symptomatic benefits, reverse remodeling of the left ventricle, reduced hospitalizations for heart failure, and improved survival. However, approximately 30% of eligible patients undergoing cardiac resynchronization therapy (CRT) do not experience clinical benefits. This article discusses recent published data that suggest that assessment of mechanical synchrony with echocardiography, especially newer techniques such as tissue Doppler echocardiography (TDE), may be a reliable and accurate means of identifying patients who will best respond to CRT. In addition, MRI provides three-dimensional information on regional mechanics and may emerge as an important technique for assessment of dyssynchrony.
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U2 - 10.1016/j.hfc.2006.02.001
DO - 10.1016/j.hfc.2006.02.001
M3 - Review article
C2 - 17386888
AN - SCOPUS:33744719401
SN - 1551-7136
VL - 2
SP - 179
EP - 192
JO - Heart Failure Clinics
JF - Heart Failure Clinics
IS - 2
ER -