Myocardial dysfunction in rheumatoid arthritis: Epidemiology and pathogenesis

Jon T. Giles, Verônica Fernandes, Joao A.C. Lima, Joan M. Bathon

Research output: Contribution to journalReview article

Abstract

Data from population- and clinic-based epidemiologic studies of rheumatoid arthritis patients suggest that individuals with rheumatoid arthritis are at risk for developing clinically evident congestive heart failure. Many established risk factors for congestive heart failure are over-represented in rheumatoid arthritis and likely account for some of the increased risk observed. In particular, data from animal models of cytokine-induced congestive heart failure have implicated the same inflammatory cytokines produced in abundance by rheumatoid synovium as the driving force behind maladaptive processes in the myocardium leading to congestive heart failure. At present, however, the direct effects of inflammatory cytokines (and rheumatoid arthritis therapies) on the myocardia of rheumatoid arthritis patients are incompletely understood.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalArthritis Research and Therapy
Volume7
Issue number5
DOIs
StatePublished - Oct 1 2005

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ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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