Myocardial collagen and its functional role

J. S. Janicki; B. B. Matsubara; A. Kabour; R. Chadwick; W. M. Chilian; E. Yellin; Y. Lanir; G. Hasenfuss; D. Kass; T. Arts

doi:10.1007/978-1-4615-2946-0_28

Myocardial collagen and its functional role

J. S. Janicki, B. B. Matsubara, A. Kabour, R. Chadwick, W. M. Chilian, E. Yellin, Y. Lanir, G. Hasenfuss, D. Kass, T. Arts

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in stiffer myocardium and ventricular diastolic dysfunction.

Original language	English (US)
Pages (from-to)	291-298
Number of pages	8
Journal	Advances in experimental medicine and biology
Volume	346
DOIs	https://doi.org/10.1007/978-1-4615-2946-0_28
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4615-2946-0_28

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title = "Myocardial collagen and its functional role",

abstract = "Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in stiffer myocardium and ventricular diastolic dysfunction.",

author = "Janicki, {J. S.} and Matsubara, {B. B.} and A. Kabour and R. Chadwick and Chilian, {W. M.} and E. Yellin and Y. Lanir and G. Hasenfuss and D. Kass and T. Arts",

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AU - Janicki, J. S.

AU - Matsubara, B. B.

AU - Kabour, A.

AU - Chadwick, R.

AU - Chilian, W. M.

AU - Yellin, E.

AU - Lanir, Y.

AU - Hasenfuss, G.

AU - Kass, D.

AU - Arts, T.

PY - 1993

Y1 - 1993

N2 - Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in stiffer myocardium and ventricular diastolic dysfunction.

AB - Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in stiffer myocardium and ventricular diastolic dysfunction.

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AN - SCOPUS:0027731354

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VL - 346

SP - 291

EP - 298

JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Myocardial collagen and its functional role

Abstract

ASJC Scopus subject areas

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