Myocardial collagen and its functional role

J. S. Janicki, B. B. Matsubara, A. Kabour, R. Chadwick, W. M. Chilian, E. Yellin, Y. Lanir, G. Hasenfuss, D. Kass, T. Arts

Research output: Contribution to journalArticlepeer-review

Abstract

Even though normally present in relatively small amounts, myocardial collagen strongly influences ventricular diastolic function. Removal of less than half of the normal amount results in a dilated ventricle with increased compliance. In contrast, an abnormal increase in collagen concentration results in stiffer myocardium and ventricular diastolic dysfunction.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalAdvances in experimental medicine and biology
Volume346
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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