Myocardial blood flow

Putting it into clinical perspective

Thomas Hellmut Schindler

Research output: Contribution to journalArticle

Abstract

In recent years, positron emission tomography/computed tomography (PET/CT)-determined myocardial perfusion in conjunction with myocardial blood flow (MBF) quantification in mL·g−1·min−1 has emerged from mere research application to initial clinical use in the detection and characterization of the coronary artery disease (CAD) process. The concurrent evaluation of MBF during vasomotor stress and at rest with the resulting myocardial flow reserve (MFR = MBF during stress/MBF at rest) expands the scope of conventional myocardial perfusion imaging not only to the detection of the most advanced and culprit CAD, as evidenced by the stress-related regional myocardial perfusion defect, but also to the less severe or intermediate stenosis in patients with multivessel CAD. Due to the non-specific nature of the hyperemic MBF and MFR, the interpretation of hyperemic flow increases with PET/CT necessitates an appropriate placement in the context with microvascular function, wall motion analysis, and eventually underlying coronary morphology in CAD patients. This review aims to provide a comprehensive overview of various diagnostic scenarios of PET/CT-determined myocardial perfusion and flow quantification in the detection and characterization of clinically manifest CAD.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalJournal of Nuclear Cardiology
DOIs
StateAccepted/In press - Dec 28 2015

Fingerprint

Coronary Artery Disease
Perfusion
Myocardial Perfusion Imaging
Pathologic Constriction
flowable hybrid composite
Research
Positron Emission Tomography Computed Tomography

Keywords

  • CAD
  • left ventricular wall motion
  • multivessel disease
  • myocardial blood flow
  • myocardial flow reserve
  • myocardial ischemia
  • positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Myocardial blood flow : Putting it into clinical perspective. / Schindler, Thomas Hellmut.

In: Journal of Nuclear Cardiology, 28.12.2015, p. 1-16.

Research output: Contribution to journalArticle

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