Myeloperoxidase as a biomarker of skin irritation and inflammation

M. A. Trush, P. A. Egner, T. W. Kensler

Research output: Contribution to journalArticle

Abstract

Topical exposure to many occupational and environmental chemicals is often accompanied by the induction of a cutaneous inflammatory response characterized by the influx of polymorphonuclear leucocytes (PMNs). In this study, the accumulation of myeloperoxidase (MPO), an enzyme found at high content in PMNs, was used as a biomarker to assess the inflammatory response to a number of well characterized skin irritants and tumour promoters. Of the chemicals examined, there was good agreement between MPO accumulation and morphometric indicators of PMNs. Therefore, it was suggested that MPO accumulation could be an additional and useful toxicological tool for determining the dermal irritancy of chemicals.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalFood and Chemical Toxicology
Volume32
Issue number2
DOIs
StatePublished - Feb 1994

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ASJC Scopus subject areas

  • Food Science
  • Toxicology

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