TY - JOUR
T1 - Myeloid suppressor cells in cancer
T2 - Recruitment, phenotype, properties, and mechanisms of immune suppression
AU - Serafini, Paolo
AU - Borrello, Ivan
AU - Bronte, Vincenzo
PY - 2006/2
Y1 - 2006/2
N2 - Growing tumors acquire the ability to resist immune recognition and immune-mediated injury. Among several mechanisms, mouse and human tumors share the ability to alter the normal hematopoiesis, leading to accumulation of cells of the myelo-monoctytic lineage at the tumor site and in different primary and secondary lymphoid organs. These cells aid tumor development by providing molecules and factors essential for tumor growth and neovascularization but also exert a profound inhibitory activity on both tumor-specific and nonspecific T lymphocytes. The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells".
AB - Growing tumors acquire the ability to resist immune recognition and immune-mediated injury. Among several mechanisms, mouse and human tumors share the ability to alter the normal hematopoiesis, leading to accumulation of cells of the myelo-monoctytic lineage at the tumor site and in different primary and secondary lymphoid organs. These cells aid tumor development by providing molecules and factors essential for tumor growth and neovascularization but also exert a profound inhibitory activity on both tumor-specific and nonspecific T lymphocytes. The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells".
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U2 - 10.1016/j.semcancer.2005.07.005
DO - 10.1016/j.semcancer.2005.07.005
M3 - Review article
C2 - 16168663
AN - SCOPUS:31344474166
SN - 1044-579X
VL - 16
SP - 53
EP - 65
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
IS - 1
ER -