Myeloid cells' evasion of melanoma immunity

Jun Wang, Lieping Chen

Research output: Contribution to journalArticle

Abstract

An immune-suppressive role of myeloid-derived suppressor cells (MDSCs) in melanoma has long been speculated, whereas molecular mechanisms underlying this role are not well understood. Here, Chung and colleagues show that dendritic cell-associated, heparan sulfate proteoglycans-dependent integrin ligand (DC-HIL), a cell surface immune-modulatory molecule, is highly expressed on tumor-associated MDSCs. Genetic ablation or antibody blockade of DC-HIL delays the growth of transplantable B16 melanoma in syngeneic mice, which is accompanied by enhanced antitumor T-cell activities. These findings support a role for DC-HIL in immune evasion within the melanoma microenvironment.

Original languageEnglish (US)
Pages (from-to)2675-2677
Number of pages3
JournalJournal of Investigative Dermatology
Volume134
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

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Heparan Sulfate Proteoglycans
T-cells
Myeloid Cells
Ablation
Integrins
Tumors
Immunity
Melanoma
Ligands
Immune Evasion
Experimental Melanomas
Molecules
Antibodies
Dendritic Cells
T-Lymphocytes
Growth
Neoplasms
Myeloid-Derived Suppressor Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Myeloid cells' evasion of melanoma immunity. / Wang, Jun; Chen, Lieping.

In: Journal of Investigative Dermatology, Vol. 134, No. 11, 01.11.2014, p. 2675-2677.

Research output: Contribution to journalArticle

Wang, Jun ; Chen, Lieping. / Myeloid cells' evasion of melanoma immunity. In: Journal of Investigative Dermatology. 2014 ; Vol. 134, No. 11. pp. 2675-2677.
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