Myelodysplastic Syndromes: Pathophysiology

Steve D. Gore, Erica Warlick

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Myelodysplastic syndromes (MDS) describe a heterogeneous and complex group of clonal bone marrow failure disorders characterized by ineffective hematopoiesis, peripheral cytopenias, morphologic dysplasia, and cellular dysfunction, often leading to increased risk of infection and transfusion requirements. They typically represent diseases of the elderly, and, while sometimes linked to known environmental exposures, are usually characterized as idiopathic. Understanding MDS pathogenesis is crucial to the development of biologically targeted therapies. This chapter explores MDS pathogenesis theories in terms of (1) the MDS cell of origin; (2) genetic alterations within the cell of origin; (3) alterations in bone marrow microenvironment and apoptosis; (4) alterations in immune surveillance; and (5) functional cellular abnormalities.

Original languageEnglish (US)
Title of host publicationLeukemias
Subtitle of host publicationPrinciples and Practice of Therapy
PublisherWiley-Blackwell
Pages77-86
Number of pages10
ISBN (Print)9781405182355
DOIs
StatePublished - Jan 4 2011

Keywords

  • Apoptosis
  • Epigenetic modulation
  • Myelodysplastic syndromes
  • Pathogenesis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Gore, S. D., & Warlick, E. (2011). Myelodysplastic Syndromes: Pathophysiology. In Leukemias: Principles and Practice of Therapy (pp. 77-86). Wiley-Blackwell. https://doi.org/10.1002/9781444327359.ch6