Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma

A. de Graeff, C. P J Vendrik, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

The incidence of secondary myelodysplastic syndromes (MDS) and acute leukaemias (AL) after chemotherapy and/or radiotherapy is increasing. Most cases have been described in patients with Hodgkin's disease, non-Hodgkin's lymphomas, multiple myeloma, polycythemia vera, ovarian cancer and breast cancer. We report 2 patients with secondary MDS and acute myeloblastic leukaemia after combined chemotherapy and radiotherapy for soft tissue sarcoma. Five more cases have been described in the literature. The data of all patients are summarized. The occurrence of secondary MDS/AL in patients with soft tissue sarcoma may become a problem, in particular in children, who have been cured after combined radiotherapy and chemotherapy.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalNetherlands Journal of Medicine
Volume34
Issue number5
StatePublished - May 1989
Externally publishedYes

Fingerprint

Myelodysplastic Syndromes
Sarcoma
Leukemia
Radiotherapy
Drug Therapy
Breast Neoplasms
Polycythemia Vera
Therapeutics
Multiple Myeloma
Hodgkin Disease
Acute Myeloid Leukemia
Ovarian Neoplasms
Non-Hodgkin's Lymphoma
Incidence

Keywords

  • Chemotherapy
  • Secondary leukaemia
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma. / de Graeff, A.; Vendrik, C. P J; Pinedo, H. M.

In: Netherlands Journal of Medicine, Vol. 34, No. 5, 05.1989, p. 251-257.

Research output: Contribution to journalArticle

de Graeff, A, Vendrik, CPJ & Pinedo, HM 1989, 'Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma', Netherlands Journal of Medicine, vol. 34, no. 5, pp. 251-257.
de Graeff, A. ; Vendrik, C. P J ; Pinedo, H. M. / Myelodysplastic syndrome and acute leukaemia following treatment of soft tissue sarcoma. In: Netherlands Journal of Medicine. 1989 ; Vol. 34, No. 5. pp. 251-257.
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