@article{7f72582c243a4ac688edbab649c8e1e4,
title = "Myelinogenic plasticity of oligodendrocyte precursor cells following spinal cord contusion injury",
abstract = "Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin repair and identity of the cells responsible remain incompletely understood and contentious. We assessed the cellular origin of new myelin by fate mapping platelet-derived growth factor receptor α (PDGFRα), Olig2+, and P0+ cells following contusion SCI in mice. Oligodendrocyte precursor cells (OPCs; PDGFRα+) produced oligodendrocytes responsible for de novo ensheathment of ~30% of myelinated spinal axons at injury epicenter 3 months after SCI, demonstrating that these resident cells are a major contributor to oligodendrocyte regeneration. OPCs also produced the majority of myelinating Schwann cells in the injured spinal cord; invasion of peripheral myelinating (P0+) Schwann cells made only a limited contribution. These findings reveal that PDGFRα+ cells perform diverse roles in CNS repair, as multi-potential progenitors that generate both classes of myelinating cells. This endogenous repair might be exploited as a therapeutic target for CNS trauma and disease.",
keywords = "Myelin, NG2 glia, OPCs, Oligodendrocytes, Schwann cells, Spinal cord injury",
author = "Peggy Assinck and Duncan, {Greg J.} and Plemel, {Jason R.} and Lee, {Michael J.} and Stratton, {Jo A.} and Manesh, {Sohrab B.} and Jie Liu and Ramer, {Leanne M.} and Kang, {Shin H.} and Bergles, {Dwight E.} and Jeff Biernaskie and Wolfram Tetzlaff",
note = "Funding Information: This work was supported by the Canadian Institutes for Health Research (CIHR; MOP-130475), the Craig H. Neilsen Foundation (D.E.B.), and the National Institutes of Health (NIH NS051509); a Frederick Banting and Charles Best Canadian Graduate Scholarship-Doctoral Award to P.A.; a Multiple Sclerosis Society of Canada Doctoral Schol-arshiptoG.J.D.;theDonnaJoanOxfordPostdoctoralFellowshipAwardfromtheMultipleSclerosisSocietyofCanada and postdoctoral fellowship awards from CIHR, T. Chen Fong, and Alberta Initiatives Health Solutions to J.R.P. We thank Dr. William Richardson (University College London, London) for the PDGFRα-CreERT2(II ) mice, Dr. Hiroshi TakebayashiviathelaboratoryofDr.ScottWhittemore(Louisville,KY)fortheOlig-2creERTMmice,andDr.UeliSuter (ETH,Z{\"u}rich)fortheP0-CreERT2mice;Drs.BrettJ.HiltonandJosephSparling,forvaluableintellectualinputs;Yuan Publisher Copyright: {\textcopyright} 2017 the authors. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2017",
month = sep,
day = "6",
doi = "10.1523/JNEUROSCI.2409-16.2017",
language = "English (US)",
volume = "37",
pages = "8635--8654",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "36",
}