@article{c42aaa6ee8254178857dff32ac7bf905,
title = "MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus",
abstract = "MyD88 is an important signaling adaptor for both TLR and IL-1R family members. Here, we evaluated the role of TLR2/MyD88 and IL-1R/MyD88 signaling in host defense against S. aureus by using a cutaneous infection model in conjunction with bioluminescent bacteria. We found that lesions of S. aureus-infected MyD88- and IL-1R-deficient mice were substantially larger with higher bacterial counts compared with wild-type mice. In contrast, TLR2-deficient mice had lesions that were only moderately larger with minimally higher bacterial counts. In addition, MyD88- and IL-1R- but not TLR2-deficient mice had severely decreased recruitment of neutrophils to the site of infection. This neutrophil recruitment was not dependent upon IL-1R/MyD88 signaling by recruited bone marrow-derived cells, suggesting that resident skin cells utilize IL-1R/MyD88 signaling to promote neutrophil recruitment.",
author = "Miller, {Lloyd S.} and O'Connell, {Ryan M.} and Gutierrez, {Miguel A.} and Pietras, {Eric M.} and Arash Shahangian and Gross, {Catherine E.} and Ajaykumar Thirumala and Cheung, {Ambrose L.} and Genhong Cheng and Modlin, {Robert L.}",
note = "Funding Information: We thank Shizuo Akira, M.D., Ph.D. (Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan) for the generous gifts of MyD88-deficient and TLR2-deficient mice. We thank Ping Fu, Christopher Creencia, and Leslie Chen at the UCLA Tissue Procurement & Histology Core Laboratory and Saeedeh Shapourifar-Tehrani, M.P.H., at the UCLA Histopathology Laboratory, for their expertise with embedding, cutting, and H&E and gram staining of tissue sections. This work was supported in part by grants R01 AI22553, R01 AI47868, and R01 AR40312 (to R.L.M.), R01 AI056154, R01 CA87924, and R01 AI052359 (to G.C.), and K08 AI62985 (to L.S.M.) from the National Institutes of Health (NIH). L.S.M. is also the recipient of a Dermatologist Investigator Research Fellowship from the Dermatology Foundation. R.M.O. and E.M.P. are supported by the U.S. Public Health Service National Research Service Award GM 07185. ",
year = "2006",
month = jan,
doi = "10.1016/j.immuni.2005.11.011",
language = "English (US)",
volume = "24",
pages = "79--91",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",
}