TY - JOUR
T1 - Mycoplasma genitalium Infection Is Not Associated With Genital Tract Inflammation Among Adolescent and Young Adult Women in Baltimore, Maryland
AU - Wang, Runzhi
AU - Trent, Maria E.
AU - Bream, Jay H.
AU - Nilles, Tricia L.
AU - Gaydos, Charlotte A.
AU - Carson, Kathryn A.
AU - Coleman, Jenell S.
N1 - Publisher Copyright:
Copyright © 2021 American Sexually Transmitted Diseases Association. All rights reserved.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Background: Mycoplasma genitalium (MG) is a prevalent sexually transmitted infection, but little is known about the associated inflammatory signatures in the genital tract of adolescents and young adult women. Methods: Adolescents and young adult women aged 13 to 24 years were recruited. Demographic information, sexual behavior history, and medical history were collected. Vaginal swab samples were tested for MG, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and measurement of 13 cytokines, chemokines, and antimicrobial proteins. Vaginal cytokine concentrations were compared by MG infection status. The strength of associations between multiple factors and MG infection was evaluated. Results: Of 215 participants, 16.7% (95% confidence interval [CI], 12.0%–22.4%) had MG infection. Inflammation was not associated with MG infection (P > 0.05). M. genitalium infection was associated with C. trachomatis infection (adjusted prevalence ratio [aPrR], 3.02; 95% CI, 1.69–5.39), bisexual behavior in the past 3 months (aPrR, 2.07; 95% CI, 1.18–3.64), genitourinary symptoms (aPrR, 2.06; 95% CI, 1.22–3.49), and self-reported Black race (aPrR, 3.53; 95% CI, 1.11–11.18). Conclusions: Higher levels of genital tract cytokines were not associated with MG infection. C. trachomatis infection, bisexual behavior, self-reported Black race, and genitourinary symptoms were associated with an increased likelihood of MG infection.
AB - Background: Mycoplasma genitalium (MG) is a prevalent sexually transmitted infection, but little is known about the associated inflammatory signatures in the genital tract of adolescents and young adult women. Methods: Adolescents and young adult women aged 13 to 24 years were recruited. Demographic information, sexual behavior history, and medical history were collected. Vaginal swab samples were tested for MG, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and measurement of 13 cytokines, chemokines, and antimicrobial proteins. Vaginal cytokine concentrations were compared by MG infection status. The strength of associations between multiple factors and MG infection was evaluated. Results: Of 215 participants, 16.7% (95% confidence interval [CI], 12.0%–22.4%) had MG infection. Inflammation was not associated with MG infection (P > 0.05). M. genitalium infection was associated with C. trachomatis infection (adjusted prevalence ratio [aPrR], 3.02; 95% CI, 1.69–5.39), bisexual behavior in the past 3 months (aPrR, 2.07; 95% CI, 1.18–3.64), genitourinary symptoms (aPrR, 2.06; 95% CI, 1.22–3.49), and self-reported Black race (aPrR, 3.53; 95% CI, 1.11–11.18). Conclusions: Higher levels of genital tract cytokines were not associated with MG infection. C. trachomatis infection, bisexual behavior, self-reported Black race, and genitourinary symptoms were associated with an increased likelihood of MG infection.
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U2 - 10.1097/OLQ.0000000000001524
DO - 10.1097/OLQ.0000000000001524
M3 - Article
C2 - 34321450
AN - SCOPUS:85123373393
SN - 0148-5717
VL - 49
SP - 139
EP - 144
JO - Sexually transmitted diseases
JF - Sexually transmitted diseases
IS - 2
ER -