Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy

Peykan Turkcuoglu, Peter Y. Chang, Zubir S. Rentiya, Roomasa Channa, Mohamed Ibrahim, Elham Hatef, Raafay Sophie, Ama Sadaka, Jianmin Wang, Yasir J. Sepah, Diana V. Do, C. Stephen Foster, Quan Dong Nguyen

Research output: Contribution to journalArticle

Abstract

Purpose: To compare the frequencies of attacks before and after immunomodulatory therapy (IMT) with mycophenolate mofetil (MMF) in recurrent punctate inner choroidopathy (PIC) and to report fundus autofluorescence (FAF) findings. Methods: Eight patients who had at least two recurrent episodes of increased activity before MMF and 12 months of documented clinical course before and after MMF were included. The frequencies of attacks before and after MMF were compared. FAF images evaluated. Results: Before MMF, the 8 patients experienced 19 attacks of recurrent disease activity; during MMF therapy, 3 (38%) patients experienced 6 recurrent episodes. The attack frequencies were 1.09±0.75 before and 0.23±0.32 during treatment (p=.036). Among the 6 patients who had FAF, surrounding hyperautofluorescent halo was detected in 4 and recurrence occurred in 2 who did not show any changes on the intensity during treatment. Conclusion: In the index study, the employment of MMF has decreased frequency of attacks in recurrent PIC. FAF may be employed to monitor and predict the response to treatment.

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalOcular Immunology and Inflammation
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2011

Keywords

  • fundus autofluorescence
  • immunomodulatory therapy
  • mycophenolate mofetil
  • punctate inner choroidopathy
  • recurrence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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  • Cite this

    Turkcuoglu, P., Chang, P. Y., Rentiya, Z. S., Channa, R., Ibrahim, M., Hatef, E., Sophie, R., Sadaka, A., Wang, J., Sepah, Y. J., Do, D. V., Foster, C. S., & Nguyen, Q. D. (2011). Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. Ocular Immunology and Inflammation, 19(4), 286-292. https://doi.org/10.3109/09273948.2011.580072