The mycotic and bacterial flora of 65 patients with cystic fibrosis was studied. C. albicans and P. aeruginosa were present in 33% and 43% of sputa samples, respectively; only 6.5% harbored both organisms. The mycotic flora of the nasopharynx, rectum and skin of the cystic fibrosis patients was similar to that of children with other chronic lung diseases and to that of normal children. In vitro studies clearly revealed inhibition of C. albicans by P. aeruginosa. It is suggested that P. aeruginosa, so prevalent with cystic fibrosis, has an inhibitory effect on C. albicans and that this interaction is effective to some extent in preventing candidal infection.
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Plant Science