Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid

Shuo Zhang, Jiazhen Chen, Peng Cui, Wanliang Shi, Xiaohong Shi, Hongxia Niu, Denise Chan, Wing Wai Yew, Wenhong Zhang, Ying Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.

Original languageEnglish (US)
Pages (from-to)2542-2544
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume60
Issue number4
DOIs
StatePublished - Apr 2016

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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