Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid

Shuo Zhang; Jiazhen Chen; Peng Cui; Wanliang Shi; Xiaohong Shi; Hongxia Niu; Denise Chan; Wing Wai Yew; Wenhong Zhang; Ying Zhang

doi:10.1128/AAC.02941-15

Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid

Shuo Zhang, Jiazhen Chen, Peng Cui, Wanliang Shi, Xiaohong Shi, Hongxia Niu, Denise Chan, Wing Wai Yew, Wenhong Zhang, Ying Zhang

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.

Original language	English (US)
Pages (from-to)	2542-2544
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02941-15
State	Published - Apr 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid",

abstract = "Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.",

author = "Shuo Zhang and Jiazhen Chen and Peng Cui and Wanliang Shi and Xiaohong Shi and Hongxia Niu and Denise Chan and Yew, {Wing Wai} and Wenhong Zhang and Ying Zhang",

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T1 - Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid

AU - Zhang, Shuo

AU - Chen, Jiazhen

AU - Cui, Peng

AU - Shi, Wanliang

AU - Shi, Xiaohong

AU - Niu, Hongxia

AU - Chan, Denise

AU - Yew, Wing Wai

AU - Zhang, Wenhong

AU - Zhang, Ying

PY - 2016/4

Y1 - 2016/4

N2 - Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.

AB - Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.

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Mycobacterium tuberculosis mutations associated with reduced susceptibility to Linezolid

Abstract

ASJC Scopus subject areas

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