Abstract
Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants of Mycobacterium tuberculosis with reduced susceptibility to LZD, which was accounted for by rrl and rplC mutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful information for the rapid detection of LZD resistance for improved treatment of MDR-TB.
Original language | English (US) |
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Pages (from-to) | 2542-2544 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 60 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2016 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases