Mycobacterium tuberculosis and human immunodeficiency virus co-infection in intravenous drug users on admission to prison

Vicente Martín, J. A. Caylà, Á Bolea, J. Castilla

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Intravenous drug users (IDUs) and prisoners are groups of great interest in human immunodeficiency virus (HIV) infection and tuberculosis (TB) epidemiology. AIM: To determine predictors and temporal trends of the co-infection of Mycobacterium tuberculosis and HIV in IDUs on admission to prison. PATIENTS AND METHODS: Between 1 January 1991 and 31 December 1997, 796 IDUs or former IDUs were studied. Socio-demographic and penitentiary variables were evaluated. HIV-positive patients with ≥5 mm induration on tuberculin test were deemed co-infected. Analysis of factors associated with co-infection was based on a logistic regression model. RESULTS: Of the incoming prisoners, 44.0% were infected by M. tuberculosis, 43.8% by HIV and 20.1% were co-infected. Co-infection predictors were: 1) total prison time served previously (none, OR 1;<2 years, OR 2.44, 95%CI 1.28-4.64; ≥2 years, OR 4.94, 95%CI 2.56-9.55); 2) age (16-25 years, OR 1; 25-29 years, OR 3.14, 95%CI 1.71-5.75; >29 years, OR 3.67, 95%CI 1.96-6.86); 3) tattoos (OR 1.56, 95%CI 0.98-2.49), 4) syringe sharing (OR 2.43, 95%CI 1.57-3.77) and 5) ex-IDU status (OR 1.87, 95%CI 1.23-2.82). No statistically significant variation in the annual co-infection tendency was observed (OR 1.10, 95%CI 0.98-1.22). CONCLUSIONS: The high prevalence of co-infection that was detected was associated with risk factors that could be amended by public health intervention.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume4
Issue number1
StatePublished - Jan 1 2000

Keywords

  • AIDS
  • Co- infection
  • Epidemiology
  • HIV infection
  • Intravenous drug users
  • Prevalence
  • Prison
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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