Mycobacterium smegmatis has two pyrazinamidase enzymes, PncA and PzaA

Ming Guo, Zhonghe Sun, Ying Zhang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The Mycobacterium smegmatis pncA gene, encoding nicotinamidase/pyrazinamidase, was identified. While it was similar to counterparts from other mycobacteria, the M. smegmatis PncA had little homology to the other M. smegmatis pyrazinamidase/nicotinamidase, encoded by the pzaA gene. Transformation of Mycobacterium bovis strain BCG with M. smegmatis pncA or pzaA conferred susceptibility to pyrazinamide.

Original languageEnglish (US)
Pages (from-to)3881-3884
Number of pages4
JournalJournal of bacteriology
Issue number13
StatePublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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